Introduction The syndrome of synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) is a rare autoinflammatory syndrome, affecting essentially the adults. Osteitis with Propionibacterium Acnes (P.Acnes) reported in the literature is generally connected to the presence of a foreign body or with the SAPHO syndrome. Chronic recurrent multifocal osteomyelitis (CRMO) is a disease related to ...

Introduction Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disorder of unknown ethiology. The clinical manifestations of CRMO are highly variable. One to 20 sites can be affected at one time. Since CNO is a systemic disorder that can affect multiple skeletal sites, whole-body imaging techniques (Tc-99 bone scintigraphy or MRI) provide major contribution to the in...

Introduction The syndrome of synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) is a rare autoinflammatory syndrome, affecting essentially the adults. Osteitis with Propionibacterium Acnes reported in the literature is generally connected to the presence of a foreign body or with the SAPHO syndrome. Chronic recurrent multifocal osteomyelitis (CRMO) is a disease related to the SAPHO ...

Chronic recurrent multifocal osteomyelitis (CRMO) is an inflammatory bone disease usually affecting children. A 9-year old boy presented with recurrent lower extremities pain and discomfort lasting for two years. In every time, symptoms vanished after several weeks. The patient received antibiotics only in one period of bone pain. In other occasions the patient didn’t received any antibiotics. ...

Introduction We report a severe case of chronic recurrent multifocal osteomyelitis (CRMO) associated with total myeloperoxidase (MPO) deficiency. The etiology of CRMO is in most cases unknown, and this is to our knowledge the first case associated with MPO-deficiency. Leukocyte MPO-deficiency renders neutrophils unable to process superoxide to secondary reactive oxygen species (ROS). Partial MP...

Introduction Chronic recurrent multifocal osteomyelitis (CRMO) is a rare autoinflammatory disorder which affects predominantly girls with peak onset between ages of 7 to 12 years. There is a frequent association of CRMO with inflammatory skin or gut disorders. Patients with isolated CRMO are usually treated with nonsteroidal antiinflammatory drugs (NSAIDs) prior to escalation to corticoids and ...

VOL. 76-B, No. 2, MARCH 1994 is often a family history of similar masses. Radiographicatty, the lesion appears as a welt-demarcated mass of lobutated, round or oval catcifications in the periarticular soft tissues. No bony abnormalities are seen and the joint space is not involved. Hyperphosphataemia is the only biochemical abnormality which has been detected (Reddy and Rao 1964; Lafferty, Reyn...