Wound care represents a significant socioeconomic burden, with over half of chronic wounds taking up to a year to heal. Measures to accelerate wound healing are beneficial to patients and also reduce the cost and burden of wound management. Epidermal grafting (EG) is an emerging option for autologous skin grafting in the outpatient setting to improve wound healing. Although several case series ...

Four patients with chronic post-operative wound infections and wound gapping that failed to respond to antibiotics were treated by allogeneic macrophage transfusions. No harmful effects were observed following macrophage transfusion and the chronic infections were eradicated in the treated patients with complete healing of wounds. Haemoglobin and white cell count were increased after cell trans...

Non-healing chronic wounds present a major biological, psychological, social, and financial burden on both individual patients and the broader health system. Pathologically extensive inflammation plays a major role in the disruption of the normal healing cascade. The causes of chronic wounds (venous, arterial, pressure, and diabetic ulcers) can be examined through a juxtaposition of normal heal...

Wound healing is a complex biological process that is generally composed of four phases: hemostasis, inflammation, proliferation, and remodeling. The proliferation phase is crucial for effective healing compared to other phases. Many critical events occur during this phase, i.e., migration of fibroblasts, re-epithelialization, angiogenesis and wound contraction. Chronic wounds are common and ar...

Wound regeneration is a typical physiological mechanism consisting of series molecular and cellular processes that take place after the commencement tissue lesion to reestablish barrier between body external surroundings. Chronic non-healing wounds, on other hand, require additional therapeutic qualities which could be obtained by using exosomes (Exo) nanoparticles (NPs) stimulate rapid superio...

Gethin G, Cowman S. Case series of use of Manuka honey in leg ulceration. Abstract The historical and current literature reports the successful use of honey to manage a diversity of wound aetiologies. However, only in the last 40 years is research on its mode of action and contribution to wound healing being investigated. The challenge of managing chronic non healing wounds generated interest i...

a systematic review was conducted covering the action of red laser, infrared and combination of both, with emphasis on cutaneous wound therapy, showing the different settings on parameters such as fluency, power, energy density, time of application, frequency mode and even the type of low-power lasers and their wavelengths. it was observed that in general, the lasers brings good clinical and hi...

Wound repair is a natural reaction to injury, which results in restoration of tissue integrity. In this study the healing effect of green tea extract formulation was investigated on open skin wound of rabbit. Active ingredients were extracted from green tea using water and glycerin (4:1) vehicle. Three cream formulations containing 2, 5 and 10% of green tea extract were prepared in the base. A ...

One important complication of diabetes mellitus is chronic, non-healing diabetic foot ulcers (DFUs). This study aims to develop and use dressings based on chitosan derivatives for the sustained delivery of neurotensin (NT), a neuropeptide that acts as an inflammatory modulator in wound healing. Three different derivatives, namely N-carboxymethyl chitosan, 5-methyl pyrrolidinone chitosan (MPC) a...