Progressive loss of renal allograft function after the first year of kidney transplant is often referred to as chronic rejection, transplant nephropathy, transplant glomerulopathy or chronic allograft nephropathy (CAN) and the use of these terms is often interchangeable. Clinically, it is usually diagnosed by a slowly rising serum creatinine level, increasing proteinuria and worsening hypertens...

AIMS/INTRODUCTION Diabetic nephropathy is one of the leading causes of end-stage renal disease. Unfortunately, reliable surrogate markers for predicting the prognostic outcome of diabetic nephropathy are as yet absent. In order to find new markers in predicting the progression of diabetic nephropathy, we carried out a prospective study by investigating the correlation between serum metabolites ...

Abstract Background This review elaborates on the definition, incidence, risk factors and treatment options for contrast-induced acute renal injury highlights potential therapeutic to prevent this condition. Contrast-induced nephropathy is a subclinical form of failure characterized by an unexplained worsening function within 48–72 h after administration iodinated contrast media. Methods A PubM...

OBJECTIVE: To review pathological approaches to the diagnosis and prognosis of primary immunoglobulin A nephropathy. DATA SOURCES: Medline and non-Medline literature search (1966-1999) and personal experience. STUDY SELECTION: The following key words were used: IgA nephropathy, pathology, grading. DATA EXTRACTION: Data were extracted and analysed independently by the authors. DATA SYNTHESIS: Pr...

BACKGROUND There is evidence that biopsy of stable renal allografts may be of value in predicting chronic allograft nephropathy, the main cause of graft loss. However, the reproducibility of such histological evaluation has not been tested in this setting. We tested the reproducibility of the Banff schema for this purpose. METHODS We rated acute and chronic changes in 184 protocol biopsies. I...

O ver my practice lifetime, a subtle but persistent change has occurred in the profile of diseases that afflict patients. We no longer are faced with saving patients from acute, catastrophic illness but rather must palliate chronic disease. While the change in life expectancy for patients with AIDS most clearly documents this shift in illness acuity, a walk through the medical floors of any hos...

Locally generated angiotensin II (AngII) may be involved in the pathogenic mechanisms of chronic renal diseases. Renal expression of AngII and other components of the renin-angiotensin system (RAS) were analyzed by immunohistochemistry and Western blot in a model of chronic progressive nephropathy induced by inhibition of nitric oxide synthesis. Renal injury was evaluated by histology and album...

OBJECTIVES Ethnic differences in the prevalence of various chronic diseases, including end-stage renal disease, have been previously reported. Surprisingly, data focusing on the lower grade of chronic kidney disease (CKD) are scarce. Thus, the aim of this study was to explore differences in the prevalence of nephropathy between the Roma and non-Roma populations. METHODS Data from the cross-se...

Relapsing polychondritis (RP) is a rare, chronic, and potentially fatal multisystemic inflammatory disorder targeting cartilaginous structures. This disorder is frequently associated with rheumatoid arthritis, systemic vasculitis, connective tissue diseases, and hematologic disorders, but renal involvement is unusual. In the literature, associated renal pathology includes mesangial expansion, I...