A cohort of 570 untreated pregnant women from Burkina Faso was studied to assess the influence of epidemiologic factors on malaria infection, which was quantified as the mean of serial, season-adjusted parasitemia measurements (mean parasite density [MPD]) carried out during the last five months of gestation. A significant effect of the area of maternal residence on the MPD was found (P < 0.003...

The V-centered bicapped hexagonal antiprism structure (A), as the most stable geometry of the cationic V15⁺ cluster, is determined by using infrared multiple photo dissociation (IR-MPD) in combination with density functional theory computations. It is found that the A structure can be stabilized by 18 delocalized 3c-2e σ-bonds on outer V₃ triangles of the bicapped hexagonal antiprism surface an...

In this paper we show that a finite p-group which possesses non-normal subgroups and such that any two non-normal subgroups of the same order are conjugate must be isomorphic to Mpn = 〈a, b | a n−1 = b = 1, n ≥ 3, a = a1+p n−2 〉, where in case p = 2 we must have n ≥ 4. This solves Problem Nr. 1261 stated by Y. Berkovich in [1]. In a similar way we solve Problem Nr. 1582 from [1] by showing that...

OBJECTIVES We conducted a systematic survey of the methodological literature to identify recommended approaches for how and what randomised clinical trial (RCT) authors should report on missing participant data and, on the basis of these approaches, to propose guidance for RCT authors. METHODS We defined missing participant data (MPD) as missing outcome data for trial participants. We conside...

JAK2, an acquired mutation of JAK2, is present in a majority of patients with polycythemia vera and to a lesser extent among patients with the other myeloproliferative disorders. We analyzed the effect of JAK2 on the expression of polycythemia rubra vera 1(PRV-1), using an in vitro model. Compared to wild-type JAK2, the presence of JAK2 increased both PRV-1 protein and mRNA levels in murine mye...

Extramedullary hematopoiesis is a complication of a number of myeloproliferative disorders. MR imaging of the orbits was performed in a patient with bilateral orbital swelling with known myeloproliferative disorder and myelofibrosis. The study revealed symmetric, bilateral enhancing masses in the lacrimal fossae extending into the nasolacrimal ducts. Biopsy demonstrated sclerotic extramedullary...

The term chronic myeloproliferative disorders was originally used by Damashek to describe the link amongst a group of acquired blood diseases. Recent molecular genetic analysis has provided a scientific basis for this observation. Underlying myeloproliferative disorders are acquired abnormalities of tyrosine kinase genes. These may be chromosomal translocations resulting in the creation of a fu...

Introduction Primary thrombocythaemia (PT) is a well recognized syndrome within the spectrum of myeloproliferative disorders. Typically presenting from middle-age onwards, difficulties may arise in differentiation from secondary thrombocytosis or other myeloproliferative states particularly in younger patients. This report of an unusual presentation ofPT in a 20-year-old male demonstrates some ...

Background Myeloproliferative disorders are a group of diseases characterized by increased proliferation of myeloid lineage. In addition to JAK2V617F mutation, several mutations in the c-MPL gene were described in patients with Philadelphia-negative chronic myeloproliferative disorders that could be important in the pathogenesis of diseases. The aim of present study was to investigate the fre...

Bone marrow biopsies of 850 patients with chronic myeloproliferative disorders were taken at initial diagnosis; and 169 sequential biopsies over periods of one to 188 months. Three micron sections of all biopsies were evaluated semiquantitatively with reference to the proliferating cell lines, anomalies of megakaryocytes, and fibrosis or osteosclerosis. Correlations between initial histological...