Chronic pain is that lasts for more than 3 months. About one quarter of kids and teens have this type pain. includes problems like frequent headaches, stomachaches, or ongoing joint muscle it often interferes with kids’ sleep, school, activities, friendships. Even though chronic can a big impact on lives, “chronic” does not mean “permanent.” Most recover from However, many are surprised to hear...

Metabolic abnormalities develop in various chronic diseases and lead to progressive catabolism with decrements in the skeletal musculature that result in muscle atrophy. We investigated pathways of skeletal muscle proteolysis using an experimental model of chronic left-ventricular dysfunction. Skeletal muscle atrophy developed in wild-type mice 12 weeks following myocardial infarction accompani...

radiation-related wounds challenge surgeons in all disciplines of surgery. wound-healing complications are commonplace, and solutions for reconstruction are limited. muscle and musculocutaneous flaps have improved this situation. but the question is, does previous radiation of the muscle to be transposed affect the outcome? 143 consecutive previously irradiated patients treated with muscle or m...

High heels are a major source of chronic lower limb pain. Yet, more than one third of all women compromise health for looks and wear high heels on a daily basis. Changing from flat footwear to high heels induces chronic muscle shortening associated with discomfort, fatigue, reduced shock absorption, and increased injury risk. However, the long-term effects of high-heeled footwear on the musculo...

BACKGROUND A persistent atrophy of muscle fibers and an accumulation of fat, collectively referred to as fatty degeneration, commonly occur in patients with chronic rotator cuff tears. The etiology of fatty degeneration and function of the residual rotator cuff musculature have not been well characterized in humans. We hypothesized that muscles from patients with chronic rotator cuff tears have...

Vascular endothelial growth factor (VEGF) is a hypoxia-inducible angiogenic mitogen. However, chronic hypoxia is generally not found to increase mammalian skeletal muscle capillarity. We sought to determine the effect of chronic hypoxia (8 wk, inspired O2 fraction = 0.12) on skeletal muscle gene expression of VEGF, its receptors (flt-1 and flk-1), basic fibroblast growth factor, and transformin...

Chronic lateral ankle instability (CAI) is defined as the occurrence of recurrent bouts instability. Clinical examination should be supplemented by a complete, directed imaging assessment. Imaging occurred simple comparative AP and weight-bearing X-ray, stress X-rays, ultrasound, CT arthrography MRI. Arthroscopic classification chronic stable ankle, moderate instability, severe global Managemen...

AIM Esophagitis is associated with an impaired esophageal peristalsis. A few studies have been aimed at understanding the pathophysiology of abnormal peristaltic activity. The mechanism of impaired esophageal smooth muscle reactivity in the chronic gastroesophageal reflux (GER) model is investigated in vitro for the first time. MATERIALS AND METHODS The chronic GER rat model was created by pa...

BACKGROUND Levels of MBCK can be increased in patients with skeletal muscle injury or renal failure in the absence of myocardial injury, causing diagnostic confusion. This study was designed to determine whether measurement of cardiac troponin I (cTnI), a myocardial regulatory protein with comparable sensitivity to MBCK, has sufficient specificity to clarify the etiology of MBCK elevations in p...