Dear Alice, I have been taking OTC cough/cold/flu preps for about a week. These all contain acetaminophen with the subsequent warnings against using if one imbibes due to possible liver damage. Is there a period of time I should wait (I'm better now) after I stop using the OTCs before I can resume enjoying my "more than 3 alcoholic beverages" per day to allow the acetaminophen to metabolize? Re...

BACKGROUND Chordoma, a rare cancer, is usually treated with surgery and/or radiation. However, very limited characterizations of chordoma cells are available due to a minimal availability (only two lines validated by now) and the extremely long doubling time. In order to overcome this situation, we successfully derived a cell line with a shorter doubling time from the first validated chordoma l...

Dear Alice, I have been taking OTC cough/cold/flu preps for about a week. These all contain acetaminophen with the subsequent warnings against using if one imbibes due to possible liver damage. Is there a period of time I should wait (I'm better now) after I stop using the OTCs before I can resume enjoying my "more than 3 alcoholic beverages" per day to allow the acetaminophen to metabolize? Re...

The results of artificial polyploidization for horticultural and agronomic plant species are presented in this review. The data on use of the classical antimitotic drug colchicine for chromosome doubling are reported. The efficacy of other compounds such as dinitroanilines and phosphorothioamidates in polyploidy induction as compared to colchicine has been summarized. The molecular basis of hig...

A. Pratap and J. Kumar (eds.), Alien Gene Transfer in Crop Plants, Volume 1: Innovations, Methods and Risk Assessment, DOI 10.1007/978-1-4614-8585-8_2, © Springer Science+Business Media New York 2014 Abstract Wide or distant hybridization has been widely used as an important tool of chromosome manipulation for crop improvement. The chromosome behaviors in F 1 hybrids provide us with the essenti...

Genome doubling (polyploidization) has played a major role in the evolution and diversification of the plant kingdom and is regarded as an important mechanism of speciation and adaptation in plants (Otto & Whitton, 2000). The term ploidy refers to the number of basic chromosome sets (represented by ‘x’) present in a somatic plant cell (2n) or gamete (n). Scaling whole sets of chromosomes up or ...

Combining the genomes of two species through hybridization and chromosome doubling can create a new allopolyploid species virtually overnight. Although common in Nature, such genetic mergers might not be easy. Recent studies, mostly in plants, suggest that polyploidization can induce a flurry of genetic and epigenetic events that include DNA sequence elimination and gene silencing. Without warn...

S OF PAPERS PRESENTED AT THE 1938 MEETINGS OF THE GENETICS SOCIETY OF AMERICA RICHMOND, VIRGINIA, DECEMBER 28-30, 1938 E. W. LINDSTROM, Secretary Ames, Iowa ANDERSON, R. L., and WHITING, P. W., Johnson C. Smith University, Charlotte, N. C. and University of Pennsylvania, Philadelphia, Pa. : Present status of linkage groups in Habrobracon.-Alleles and linked genes with direction right or left un...