This Practice Bulletin was developed by the ACOG Committee on Practice Bulletins—Obstetrics, the ACOG Committee on Genetics, and the Society for Maternal–Fetal Medicine Publications Committee with the assistance of Ray Bahado-Singh, MD, and Deborah Driscoll, MD. The information is designed to aid practitioners in making decisions about appropriate obstetric and gynecologic care. These guideline...

background: the secondary genetic changes other than the promyelocytic leukemia-retinoic acid receptor (pml-rara) fusion gene may contribute to the acute promyelocytic leukemogenesis. chromosomal alterations and mutation of flt3 (fms-like tyrosine kinase 3) tyrosine kinase receptor are the frequent genetic alterations in acute myeloid leukemia. however, the prognostic significance of flt3 mutat...

Abstract Background Much interest has not been placed on the role of chromosomal abnormalities in pathogenesis and rising prevalence infertility recent times. This review was conducted to renew public basis infertility, testing, management. Main text Meiotic post-zygotic mitotic errors may cause infertility-predisposing abnormalities, including Klinefelter syndrome, Jacob Triple X Turner Down s...

Background and Objectives: studying chromosomal changes for anemia patients of children age (3month-12years ) in the city kut diagnosing those abnormalities resulting from having Methods: The chromosomes Patients to were analyzed studied using cytogenetic analysis detect aberrations caused by after collecting blood samples Al-Karama Teaching Hospital as well clinics Kut.Results: Chromosomal all...

Tumors of the pineal region represent about 0.4-1% of intracranial neoplasms, including those tumors of germ cell origin (primarily germinomas and teratomas, which represent about 80% of pineal malignancies), and those tumors of the pineal parenchyma (pineocytoma and pineoblastoma). Pineocytoma is composed of relatively mature cells of the pineal parenchyma, whereas pineoblastoma represents a m...

Numerous neoplastic states have associated or causal cytogenetic abnormalities. In some cancers, specific chromosomal abnormalities appear to correlate with the clinical characteristics and prognosis. Cytogenetic analysis of Hodgkin's disease is thought to be technically difficult and only a small number of cases with evaluable results have been reported. We have attempted cytogenetic studies o...

This Practice Bulletin was developed by the ACOG Committee on Practice Bulletins—Obstetrics, the ACOG Com mittee on Genetics, and the Society for Maternal–Fetal Medicine Publications Com mit tee with the assistance of Ray Bahado-Singh, MD, and Deborah Driscoll, MD. The in for ma tion is de signed to aid practitioners in making decisions about appropriate obstetric and gyneco logic care. These g...

introduction: most of the hematologic malignancies are heterogenous with regard to morphology, immunophenotype, and genetic rearrangements. multiple recurrent chromosomal aberrations have been identified by conventional cytogenetic analysis, which is now widely recognized as one of the most important diagnostic and prognostic determinants in these patients. patients and methods: bone marrow sam...

Mutagenic effectiveness of gamma rays on Allium cepa was studied. The seeds were treated with five doses (viz. 5kR, 10kR, 15 kR, 20kR and 25kR) of gamma rays. Chromosomal abnormalities were observed. Chromosomal aberrations like, dicentric, tricentric, ring, minute, deletion, fragment, laggard, bridge and micronuclei were noticed in treated root tip mitosis. The chromosomal abnormalities were i...