نتایج جستجو برای: chondroitinase abc
تعداد نتایج: 15466 فیلتر نتایج به سال:
A biotin-labelled proteoglycan fraction which contained both GlcNAc and GalNAc was treated by sequential addition of chondroitinase AC/ABC and heparinase/heparitinase (Seikagaku, Tokyo, Japan) (Kato et al., 1985; Oike et al., 1080). A sharp band at the entrance of the separation gel in the untreated sample (Fig. 1; lane 1 ) is nearly abolished after chondroitinase treatment (Fig. 1: lane 2). A ...
Chondroitin sulphate proteoglycans (CSPGs) are known to be important contributors to the intensely inhibitory environment that prevents tissue repair and regeneration following spinal cord injury. The bacterial enzyme chondroitinase ABC (ChABC) degrades these inhibitory molecules and has repeatedly been shown to promote functional recovery in a number of spinal cord injury models. However, when...
Damage to the adult CNS often causes devastating and permanent deficits because of the limited capacity of the brain for anatomical reorganization. The finding that collateral sprouting of uninjured fiber tracts mediates recovery of function prompts the search for experimental strategies that stimulate axonal plasticity after CNS trauma. Here we characterize treatments that promote the sproutin...
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