Previous studies have demonstrated a variable effect of fish oil on low density lipoprotein (LDL) cholesterol and apolipoprotein (apo) B levels, particularly in hypertriglyceridemic subjects. Since heterogeneity of LDL composition and metabolism in hypertriglyceridemic subjects is well described, the present study was undertaken to determine if the response of LDL to dietary fish-oil supplement...

Unilamellar lipid vesicles of various cholesterol:phosphatidylcholine molar ratios were used to alter, via passive exchange at the plasma membrane, the cellular free cholesterol content of cultured human skin fibroblasts which had been preincubated in lipoprotein-deficient serum. The effects of these net surface transfers of cholesterol on cellular cholesterol biosynthesis, cholesterol esterifi...

Pectin (PE), guar gum (CC), and psyllium (PSY) lower plasma low density lipoprotein (LDL) cholesterol concentrations in guinea pigs with different orders of magnitude by inducing defined alterations in hepatic cholesterol homeostasis (Fernandez et al. 1994. Am.J Clin. Nutr. 59: 869-879; 61: 127-134 and 1995.J Lipid Res. 3 6 1128-1138). To further explore specific mechanisms responsible for the ...

Hijamah or cupping therapy has a therapeutic effect on cholesterol. However, there is still lack of studies that investigate the potential in managing apolipoprotein B as proatherogenic agent and A-1 an anti-proatherogenic agent. This study aims to explore lipid profiles apolipoproteins hypercholesterolemic patients. A pre-post experimental design without controls were used. Consecutive samplin...

Background and Aims : Angiopoietin-like protein 3 (ANGPTL3) inhibition reduces LDL-cholesterol (LDL-C), triglycerides (TG) HDL-C in patients with hyperlipidemia. Post-prandially, ANGPTL8 forms a complex ANGPTL3; the ANGPTL3/8 inhibits lipoprotein lipase 100-fold more potently circulates at much lower levels than ANGPTL3 alone. This phase 1 study assessed safety pharmacology of single ascending ...

1. Phenobarbitone in a dose of 180 mg daily was administered to ten normal subjects for 3 weeks. There was a significant increase in total plasma cholesterol, plasma low-density-lipoprotein cholesterol, plasma low-density-lipoprotein (LDL) triglycerides and plasma LDL protein. The increase in plasma LDL cholesterol accounted for the increase in total plasma cholesterol. There was a significant ...

regarding the high prevalence of hyperlipidaemia, which is one of the major risk factors of cardiovascular disease, and uncertain reports about the relation between periodontal disease and serum lipid profile, this study was conducted to assess this relation. the historical cohort study was conducted on 52 cases including 26 persons with chronic periodontitis as case group, and 26 healthy subje...

background : the excessive changes in serum of lipids, lipoproteins and apolipproteins can be considered as strong risk factors for cardiovascular diseases.in particularlipoproteins can determine the risk of cardiovascular illnesses in teenyears (before showing clinical symptoms).studies have shown that the serum level of ldl c -hdl c is a function of the productionamount of apoa 1 and apob 100...

Background: The Lipid Regulatory Hypothesis (LRH) states that the best way to regress atherosclerotic plaque is to simultaneously decrease the cholesterol being transported into the arterial wall by low-density lipoprotein (LDL) and increase the cholesterol being removed from the arterial wall, via reverse cholesterol transport, by high-density lipoprotein (HDL). The cholesterol retention fract...