Aim of the study Assessment of the expression of cluster of differentiation (CD)3, CD4, and CD8 T cells in biliary atresia (BA) cases in comparison to neonatal cholestasis other than BA. Material and methods This study included 79 patients: 34 patients with BA (BA group) and 35 patients with neonatal cholestasis due to causes other than BA (cholestasis group), and 10 normal liver donor as a c...

Cholestasis, or impaired bile flow, is an important but poorly understood manifestation of liver disease. Two clinically distinct forms of inherited cholestasis, benign recurrent intrahepatic cholestasis (BRIC) and progressive familial intrahepatic cholestasis type 1 (PFIC1), were previously mapped to 18q21. Haplotype analysis narrowed the candidate region for both diseases to the same interval...

Objective: To report the mutational landscape of a clinically diagnosed cohort paediatric patients with cholestasis liver diseases. Method: The retrospective study was conducted at University Child Health Sciences, Children Hospital, Lahore, Pakistan, from December 10, 2021, to March 31, 2022, and comprised data collected Paediatric Gastroenterology Hepatology unit on demographics, clinical lab...

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy specific liver disorder characterized by maternal pruritus in the latter half of the pregnancy, raised serum bile acids and increased rates of adverse fetal outcomes. Maternal effects of ICP are mild; however, there is a clear association between ICP and higher frequency of fetal distress, preterm delivery, and sudden intrauterin fetal ...

Class III multidrug resistance P-glycoproteins, mdr2 in mice and MDR3 in human, are canalicular phospholipid translocators involved in biliary phospholipid (phosphatidylcholine) excretion.The role of a MDR3 (ABCB4) gene defect in liver disease has been initially proven in a subtype of progressive familial intrahepatic cholestasis called PFIC3, a severe pediatric liver disease that may require l...

A major function of the liver is the formation of bile and hepatobiliary excretion of endogenous substances and xenobiotics, such as chemicals, drugs, and their metabolites. Cholestasis is a general condition of multiple etiologies, hereditary and acquired, in which bile excretion from the liver is attenuated or blocked. In some forms of cholestasis, cholesterol metabolism is perturbed, resulti...