The issue of antipsychotics in psychiatry constituted a revolution at the time. The firsts, starting with chlorpromazine represent the conventional antipsychotics, in the last decades there was a new generation of antipsychotics, atypical, which improved the results in treating psychoses. Because, as any drug, it may have adverse effects we aimed an experimental study on rats to observe the tox...

In the previous paper (Dawkins, Judah & Rees, 1959) it was shown that 10-(3-dimethylaminopropyl)-2-chlorophenothiazine (chlorpromazine) was an inhibitor of cytochrome oxidase and also exhibited some action against oxidative phosphorylation. During the course of this investigation, it became apparent that chlorpromazine also had a second point of action in the respiratory chain. This paper descr...

This brief review frames the historical context surrounding antipsychotic medication for patients in nursing homes and other long-term care settings. The information is meant to describe, concisely, the evidence for and against the use of antipsychotic treatment. Every patient’s experience is distinctive, and each treatmentdecision has potential benefits and risks. The first antipsychotic medic...

It was synthesized by M/s Rhone Poulence Laboratories of Paris, to meet the demand for a drug that will be effective in the prcvention and/or treatment of surgical shock, This was sought to be achicved by damping out the homeostalic regulating reactions including those under the control of the hypothalamus, by Ihe use of a suitable pharmacodynamic agent, supplemented by induced hypothermia. CPZ...

IN INDLA cataract surgery is a major problem. We consider any person above 60 years of age as a potential cataract patient if he is not one already. Through lack of education, the cooperation of the patient in intra-ocular surgery is not all one would like it to be, and it is therefore best not to rely on the patient's cooperation but to administer suitable sedatives. Chlorpromazine promises to...

Chlorpromazine is a classical neuroleptic drug which produces both therapeutic effects as well as unwanted side effects in human such as sedation, autonomic, endocrine and neurological effects. It is thought that blockade of dopamine D-2 receptors caused by chlorpromazine induces these untoward side effects. Pre-clinical studies on catalepsy has been proposed as an animal model for neuroleptic ...

Pharmacological properties of 2 amino-4-[4-(2-hydroxyethyl)-piperazin-1-yl]-6-trifluoromethyl-s-triazine (TR-10) were investigated in mice and rats. Chlorpromazine served as a reference compound. Tr-10 expressed in general the pharmacological profiles as neuroleptic ascertained by anti-methamphetamine activity, supression of conditioned avoidance response, taming effects, decrease in explorator...