The objective of this paper is to emphasize the fact that while consistent interest has been paid to the industrial use of chitosan, minor attention has been devoted to spread the knowledge of a good characterization of its physico-chemical properties. Therefore, the paper attempts to critically comment on the conflicting experimental results, highlighting the facts, the myths and the controver...

OBJECTIVE The objective of the research was to formulate and evaluate sumatriptan succinate-loaded chitosan nanoparticles for migraine therapy in order to improve its therapeutic effect and reduce dosing frequency. MATERIAL AND METHODS The Taguchi method design of experiments (L9 orthogonal array) was applied to obtain the optimized formulation. The sumatriptan succinate-loaded chitosan nanop...

chitosan with excellent biodegradable and biocompatible characteristics has received attention as an oral drug delivery vehicle for controlled-release formulations. in this study an enteric-coated capsule containing theophylline-chitosan beads based on 23 factorial designs was prepared as a colon drug delivery system. the theophylline-chitosan gel beads were formulated by adding the drug-contai...

Objectives: To assess and compare the quantity quality of newly bone generated when using chitosan-based gel scaffold osteoprotegerin-chitosan scaffold. Methods: A total 18 critical-sized defects on New Zealand white rabbit craniums were created. In 12 defects, either chitosan or was implanted last six kept unfilled as a control. Bone formation examined at 6 weeks. Bone’s specimens scanned High...

The vaginal route of administration is an alternative for several treatments for either local or systemic pharmacological effects. However, the permanence of a drug in this route represents a challenge for formulation development that can be overcome by using nanoencapsulation and chitosan gel. Thus, this work aimed to evaluate the performance of chitosan hydrogels containing cationic and anion...

In this work, aldehyde-functionalized chitosan was produced by the reaction of chitosan in the solid state with nitrogen oxide gases, generated in situ from a HNO3/H3PO4 NaNO2 mixture. This reaction is more advantageous than the existing methods to produce aldehyde-functionalized chitosan, since the depolymerization was slower and the purification process of the products was easy and straightfo...

To increase the low bioavailability and short ocular residence time of ciprofloxacin eye drops, aqueous solutions of drug in chitosan/ Pluronic (poloxamer) were prepared to identify suitable compositions with regard to gel forming properties and drug release behavior. Mixtures of solutions of Pluronic (10-25% w/w) with chitosan (0.1-0.3% w/w) of different molecular weights (Mw) were prepared. C...

BACKGROUND The development of tissue engineering scaffolds for gene delivery has the potential to enhance gene transfer efficiency and safety via controlled temporal and spatial delivery. Lentiviral delivery can be carried out using the natural biopolymer thermoresponsive gel, chitosan/β-glycerol phosphate (β-GP) as a carrier. METHODS Three chitosan/β-GP scaffolds were prepared with varying c...

Poor water solubility and low transfection efficiency of chitosan are major drawbacks for its use as a gene delivery carrier. PEGylation can increase its solubility, and folate conjugation may improve gene transfection efficiency due to promoted uptake of folate receptor-bearing tumor cells. The aim of this study was to synthesize and characterize folate-poly(ethylene glycol)-grafted chitosan (...

Chitosan is a cationic natural polysaccharide which is derived from the chitin of crustaceans, with crabs and shrimp-shell wastes as its principal source. Its properties includes extent of deacetylation and the average molecular weight of polymer as well as low toxicity and good bioavailability make it a novel excipient in pharmaceutical formulation as a relatively new development. Together wit...