Dear Sir: We read with much interest the review by J.Potter on ‘The failure of cancer chemoprevention’ (1). We, as well as most researchers working in the area of cancer chemoprevention, are as frustrated as Dr J.Potter is, about the lack of unequivocal evidence of a high benefit/ harm effect of cancer chemoprevention in clinical trials. However, we strongly feel that the failure of cancer chem...

Twenty-five years ago, as the “War on Cancer” began, there was hope and anticipation that the mortality rates for common forms of cancer might be greatly reduced by the year 2000. Although this goal has not been attained, a primary result of the increased funding for cancer research during the past 25 years has been an immense increase in knowledge of the mechanisms whereby normal cells and tis...

Cancer of the lung causes more deaths from cancer worldwide than at any other site. The environmental, genetic, and dietary risk factors are discussed and progress in chemoprevention is reviewed. A better understanding of the molecular events that occur during carcinogenesis has opened up new areas of research in cancer prevention and a number of biochemical markers of high risk individuals hav...

Cancer of the lung causes more deaths from cancer worldwide than at any other site. The environmental, genetic, and dietary risk factors are discussed and progress in chemoprevention is reviewed. A better understanding of the molecular events that occur during carcinogenesis has opened up new areas of research in cancer prevention and a number of biochemical markers of high risk individuals hav...

Cancer is the second deadliest disease in world with very high potential of prevention. The past few decades have witnessed an increased interest cancer chemoprevention among researchers, clinicians and public because a successful prevention strategy could save millions lives. This new paradigm has led to critical evaluation prospective chemopreventive agents including natural dietary agents, m...

Cancer chemoprevention refers to the use of agents for the inhibition, delay, or reversal of carcinogenesis before invasion. In the present review, agents examined in the context of cancer chemoprevention are classified in four major categories-hormonal, medications, diet-related agents, and vaccines-and the main representatives of each category are presented. Although there are serious constra...

In this issue 1-4 A Better Future For Lung CAnCer Chemoprevention 5-7 SeLeCtionS From the peer-reviewed LiterAture 8 Continuing mediCAL eduCAtion eventS 8 Lung CAnCer meetingS And SympoSiA Lung cancer is the leading cause of cancer death in men and women in the United States, as well as worldwide, and approximately 85% of cases are attributable to cigarette smoking. Even after smoking cessation...

Lung cancer is responsible for over one million deaths worldwide each year. Smoking cessation for lung cancer prevention remains key, but it is increasingly acknowledged that prevention strategies also need to focus on high-risk groups, including ex-smokers, and patients who have undergone resection of a primary tumor. Models for chemoprevention of lung cancer often present conflicting results,...

Together, gastrointestinal (GI) cancers now account for 25% of neoplastic deaths in the West. In Poland, GI cancer rates are likely to increase further as westernization progresses. Given that conventional cancer therapies have made only modest reductions in cancer mortality, there is a great interest in chemoprevention to prevent or slow malignant transformation from premalignant lesions. The ...

Cancer chemoprevention is a new discipline whose foundation rests upon epidemiologic evidence suggesting that dietary components such as beta-carotene, vitamin E, calcium and selenium may be inhibitors of carcinogenesis. Over the last decade, as molecular and biochemical mechanisms of the carcinogenesis process have been elucidated, the rationale of combining chemopreventive agents to target mu...