A NIR-chemometric method, that is able to directly quantify the active pharmaceutical ingredient (API) and two major excipients in pharmaceutical powder blends for manufacturing indapamide sustained release (SR) tablets, was developed and fully validated. In order to develop calibration models for the assay of indapamide, hydroxypropylmehylcelulose (HPMC) and lactose, the NIR spectra of 25 seri...

This paper presents the application of metabolomic techniques to determine the presence of microbial influenced corrosion (MIC). In a previous study, the extracellular metabolites expressed from pipe biofilm was identified by analysing the passing water. This investigation extends this work by successfully applying a chemometric statistical analysis to the extracellular metabolomic profile of a...

FT Raman spectroscopy was used for the investigation of cellulose and cellulose derivates. Lattice structures of cellulose, polymorphic modifications I and II, as well as amorphous structure were clearly identified by means of FT Raman vibrational spectra. Chemometric models were developed utilizing univariate calibration as well as methods of multivariate data analyses of the FT Raman spectral...

Hydrolysable tannins, total phenols and flavonoids in Eugenia uniflora leaves were monthly analysed for one year. The results were correlated with climate conditions (rainfall, humidity, cloudiness and mean temperature) through chemometric methods. Principal component analysis revealed high levels of hydrolysable tannins in the rainy season, whereas flavonoids were mainly produced in the dry se...