A new field of science, chemical biology/ chemical genetics/ chemical genomics (cb/cg/cg) has emerged since the late 1990's, especially in the United States. The NIH Roadmap agenda, Molecular Libraries Screening Center Network (MLSCN), became a drive force to push cb/cg/cg forward. Cb/cg/cg studies consist of three methodologies, chemical libraries with small molecules, high-throughput screenin...

Introdução: Relatado primeiramente em 1927 por Kubo, no Japão. O cisto cirúrgico ciliado (CCC) esta associado a procedimento anterior, sendo mais prevalente na população asiática. Objetivo: Relatar um caso de CCC Brasileiro, leucoderma 42 anos que desenvolveu lesão 12 após ser submetido à osteotomia Le Fort I. Relato caso: J.E.S.B 35 anos, normossistêmico, foi cirurgia ortognática 2007, realiza...

O líquén plano oral é uma doença mucocutânea, de curso crônico, responsável por destruir a camada basal do epitélio e, quando não controlada, predispões à malignização. Apesar da sua etiologia incerta, o estresse e ansiedade têm sido frequentemente evidenciados como fatores promotores para essa patologia. Dessa forma, esse estudo tem objetivo relatar um caso paciente masculino com Líquen (LPO) ...

INTRODUÇÃO: A Neurofibromatose tipo II (NF2) é uma sindrome autossômica dominante, causada pela mutaçãodo gene NF2 no cromossomo 22, que resulta na disfunção da codificação proteína merlina. Esta doença pode ter expressões patológicas variadas, necessitando de atenção multidisciplinar melhorando os resultados dos tratamentos. O diagnóstico realizado por meio ligações genéticas, considerando o r...

in this research at the first, captopril drug (ca) and its fullerene connected form (fca) wereoptimized. natural bond orbital (nbo) calculations for these compounds were carried out at theb3lyp/6-31g quantum chemistry level, in the gas phase and the liquid phase. these calculations canbe performed at different accuracy levels depending on the aim of the theoretical study [1]. forinstance, densi...

alcohol in iran is produced mainly from molasses of sugar cane and sugar beet. other sources of alcohol production like wheat and barley exist, but because of some cultural and political reasons, they cannot be legally used for producing alcohol in iran. twenty-six manufacturers in 18 provinces are officially active. the actual capacity of ethanol production with medical purity is about 100mill...

A 52-year-old man, living in a rural area near Okayama, was admitted to hospital for assessment of a pulmonary shadow found at annual chest radiography. He had been a farmer for 21 years and then a public worker for 10 years. He had smoked one packet of cigarettes daily for 30 years but was otherwise well and free from symptoms. Physical examination disclosed no abnormality apart from a circums...

Lichen sclerosus et atrophicus was first described by Hallopeau (1887), who regarded it as a variant of lichen planus. Ormsby (1910), however, considered it to be a separate disease entity. Stuhmer (1928) used the term "balanitis xerotica obliterans" to describe a case in which there was progressive sclerosis and atrophy of the glans penis and preputial remains following an operation for congen...