Both society and industry are interested in increasing the safety of pharmaceuticals. Potentially dangerous compounds could be filtered out at early stages of R&D by computer prediction of biological activity and ADMET characteristics. Accuracy of such predictions strongly depends on the quality & quantity of information contained in a training set. Suggestion that some relevant chemical inform...

sterilized soils are commonly used for the study of xenobiotic sorption and as an abiotic control in biodegradation experiments. they are also used for the chemical study of nitrogen and carbon cycle processes and the elimination of the biological factors. in this research the effects of different soil sterilization methods such as autoclaving, fumigating and exposure to ultraviolet and microwa...

In this study, ion exchange nanocomposite membranes was prepared by addition of Mg(OH)2 nanoparticles to a blend containing sulfonated polyphenylene oxide and sulfonated polyvinylchloride via a simple casting method. Magnesium hydroxide nanoparticles were synthesized via a facile sono-chemical reaction and were selected as filler additive in fabrication of ion exchange nanocomposite membranes. ...

The mechanism by which mechanical force regulates the kinetics of a chemical reaction is unknown. Here, we use single-molecule force-clamp spectroscopy and protein engineering to study the effect of force on the kinetics of thiol/disulfide exchange. Reduction of disulfide bonds through the thiol/disulfide exchange chemical reaction is crucial in regulating protein function and is known to occur...

The kinetics of water exchange across the membrane of class II chloroplasts has been studied by two NMR methods. Both methods utilize Dy(en)3+ (en = ethylenediamine) to induce a transmembranal chemical shift the order of 40 Hz in the water proton resonance. The shift reagent is impermeant to the chloroplast membrane, inert as a redox reagent, soluble at millimolar concentrations at neutral pH, ...

CatalyCEST MRI can detect enzyme activity by monitoring the change in chemical exchange with water after a contrast agent is cleaved by an enzyme. Often these molecules use paramagnetic metals and are delivered with an additional non-responsive reference molecule. To improve this approach for molecular imaging, a single diamagnetic agent with enzyme-responsive and enzyme-unresponsive CEST signa...

Sterilized soils are commonly used for the study of xenobiotic sorption and as an abiotic control in biodegradation experiments. They are also used for the chemical study of nitrogen and carbon cycle processes and the elimination of the biological factors. In this research the effects of different soil sterilization methods such as autoclaving, fumigating and exposure to ultraviolet and microwa...