Background: Concurrent chemoradiotherapy (CCRT) plus intracavitary brachytherapy (ICBT) is standard of care for locally advanced cervical cancer (LACC). However, because differences in tissue response and anatomy, sometimes fails to deliver adequate doses may result higher recurrence rates. Thus, there have been studies discussing the role adjuvant hysterectomy (AH). National Comprehensive Canc...

BACKGROUND Cervical cancer is the leading cause of cancer related deaths among women in India. Limited reports are available for Notch-1 and Notch-3 protein in cervical carcinoma, which play crucial role in cell proliferation, differentiation, and apoptosis. METHODS This study was designed to evaluate the role of Notch-1 and Notch-3 with context to HPV infection in cervical carcinoma. A total...

abstract background and aims: cervical cancer is among leading causes of cancer related death in women and human papilloma virus (hpv) is one of the important risk factor of this cancer. the aim of the present study was to develop a pcr method for identification of a high carcinogenic type of hpv, hpv 18 using e6 gene as a marker in patients with cervical cancer materials and methods: 92 formal...

from december 2000 until 2010, the researchers at royan institute conducted a wide range of investigations on ovarian tissue cryopreservation with the intent to provide fertility preservation to cancer patients that were considered to be candidates for these services. in 2010, royan institute established the royan human ovarian tissue bank as a subgroup of the embryology department. since its i...

conclusions the high prevalence of hpv in abnormal cytology underlines to the fact that the presence of hpv is a critical factor in the development of cervical cancer. the use of hpv dna techniques could actually become an effective and fast means of ascertaining the presence of hpv in abnormal cytology. results result showed a 100% presence of high risk hpv in all the samples with abnormal cyt...

Human papillomavirus (HPV) infection alone is not sufficient for development of cervical cancer and further risk factors are involved, however, the underlying mechanism remains to be elucidated. The authors previously used a microarray assay to reveal microR‑20b (miR‑20b) as a key node in the miRNA‑mRNA network of cervical carcinoma. The present study demonstrated an increased expression of miR...

BACKGROUND Cervical cancer is a chronic inflammatory disease of multifactorial etiology usually presenting in sexually active women. Exposure of neoplastic cervical epithelial cells to seminal plasma (SP) has been shown to promote the growth of cancer cells in vitro and tumors in vivo by inducing the expression of inflammatory mediators including pro-inflammatory cytokines. IL-1α is a pleotropi...

background : cervical cancer is the second most common cancer among women in the world and the most common cancer in developing countries. pap smear is and effective tool that can prevent death due to cervical cancer . the aim of this study was to determine the factors related to doing regular pap-smear test based on the theory of planned behavior . methods : in this cross-sectional study, cond...

background: organized cervical screening program has led to prevention of cervical cancer prevention worldwide. women’s knowledge and attitudes is linked to their participation in cervical screening. objective: we studied the knowledge, attitudes and practices (kap) of women about cervical cancer prevention and the related factors in tehran, i.r. of iran. methods: trained interviewers used a va...