1. A description is given of the construction details and operation characteristics of an improved type of air-driven ultracentrifuge operating in vacuum and suitable for the determination of sedimentation constants of protein molecules. 2. The rotor of the centrifuge is made of a forged aluminum alloy; it is oval in shape, measures 185 mm. at its greatest diameter, and weighs 3,430 gm. It carr...

This article presents an analytical model, originally developed in the 1980s, for the gas centrifuge and uses this methodology to determine the main design and operational characteristics of several hypothetical centrifuge designs. A series of simulations for a typical first-generation machine is used to assess the relevance of important breakout scenarios, including batch recycling and cascade...

We present an experimental analysis of the effects of gravity level on the formation and rise dynamics of bubbles. Experiments were carried out with millimeter-diameter bubbles in the hypergravity environment provided by the large-diameter centrifuge of the European Space Agency. Bubble detachment from a nozzle is determined by buoyancy and surface tension forces regardless of the gravity level...

Purpose We test the ability of next-generation sequencing, combined with computational analysis, to identify a range of organisms causing infectious keratitis. Methods This retrospective study evaluated 16 cases of infectious keratitis and four control corneas in formalin-fixed tissues from the pathology laboratory. Infectious cases also were analyzed in the microbiology laboratory using cult...

The mechanical behavior of saturated soil is mainly governed by the interaction between the soil skeleton and the pore fluid, and this interaction may lead to significant loss of strength known as liquefaction under seismic loading conditions. The main objective of this paper is to implement a cyclic constitutive model based on fuzzy set plasticity theory, which is capable of modeling soil dila...

Centrifuges are used for 1 x g controls in space flight microgravity experiments and in ground based research. Using centrifugation as a tool to generate an Earth like acceleration introduces unwanted inertial shear forces to the sample. Depending on the centrifuge and the geometry of the experiment hardware used these shear forces contribute significantly to the total force acting on the cells...