OBJECTIVES To evaluate the cardiac safety of central nervous system stimulants in children and adolescents. DESIGN Population based retrospective cohort study. SETTING Automated healthcare claims data from 1,219,847 children and young people eligible for 28 state Medicaid programmes from 1999 to 2006 linked to the Social Security Death Master File and the National Death Index. PARTICIPANT...

USE OF d-AMPHETAMINE AND RELATED CENTRAL NERVOUS SYSTEM STIMULANTS IN CHILDREN T HE abuse of amphetamines has become a problem of international significance. Japan was the first country to recognize this problem, and by 1954 there were an estimated 500,000 to 600,000 abusers in Japan. More than ten years ago Japan banned the use of amphetamines. The United Kingdom restricted distribution of amp...

USE OF d-AMPHETAMINE AND RELATED CENTRAL NERVOUS SYSTEM STIMULANTS IN CHILDREN T HE abuse of amphetamines has become a problem of international significance. Japan was the first country to recognize this problem, and by 1954 there were an estimated 500,000 to 600,000 abusers in Japan. More than ten years ago Japan banned the use of amphetamines. The United Kingdom restricted distribution of amp...

A large body of evidence supports the hypothesis that mesolimbic dopamine (DA) mediates, in animal models, the reinforcing effects of central nervous system stimulants such as cocaine and amphetamine. The role DA plays in mediating amphetamine-type subjective effects of stimulants in humans remains to be established. Both amphetamine and cocaine increase norepinephrine (NE) via stimulation of r...

USE OF d-AMPHETAMINE AND RELATED CENTRAL NERVOUS SYSTEM STIMULANTS IN CHILDREN T HE abuse of amphetamines has become a problem of international significance. Japan was the first country to recognize this problem, and by 1954 there were an estimated 500,000 to 600,000 abusers in Japan. More than ten years ago Japan banned the use of amphetamines. The United Kingdom restricted distribution of amp...

attention-deficit/hyperactivity disorder (adhd) is a highly heritable neuropsychiatric disorder associated with significant impairments in occu pational, academic, neuropsychological, and social functioning. central nervous system (cns) stimulants are recommended as first-line medication therapy for children. cns stimulants include formulations of methylphenidate and amphetamine derivatives and...

OBJECTIVE To determine the influence of the use of central nervous system (CNS) stimulants on visual functions and occurrence of road traffic accidents (RTA) amongst commercial drivers. DESIGN A cross-sectional study in which two hundred and fifteen consecutive drivers were interviewed and their eyes examined. SETTINGS Ife Central Local Government Area (LGA) of Osun State, Nigeria. MATERI...

Neural stem cells are undifferentiated cells that are located in limited areas of central nervous system. These cells have proliferation and self-renew ability and can be differentiated into neurons and glial cells. Mature nerve cells do not have proliferative ability; and due to the limited number of nerve stem cells, injuries to the nervous system are not recoverable. The purpose of this revi...

24. Introduction to Central Nervous System Pharmacology 281 Charles R. Craig 25.General Anesthesia: Intravenous and Inhalational Agents 291 David J. Smith and Michael B. Howie 26.Opioid and Nonopioid Analgesics 310 Sandra P. Welch and Billy R. Martin 27.Local Anesthetics 330 J. David Haddox 28.Agents Affecting Neuromuscular Transmission 338 Michael D. Miyamoto 29.Central Nervous System Stimulan...