Enhanced immune cell trafficking into the central nervous system (CNS) and disruption of the blood brain barrier are pathophysiological hallmarks of neuroinflammatory disorders like multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). However, recent studies suggest that the coagulation and the contact-kinin system might also be involved in MS developme...

Movement is the result of muscle contractions that are controlled by the nervous system. The nervous system consists of two parts (Figure 1): the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS is regarded to be the neural control center for movement. On the basis of sensory information supplied by the PNS concerning the state of the musculoskeletal system and the ...

Multiple Sclerosis (MS) is an autoimmune disease, which is characterized by demyelination and neuroinflammation. Extracellular Matrix (ECM) have important role in the central nervous system (CNS). Alterations are happening to the ECM after the CNS disorder like MS, Alzheimer and other neural injury. Tenasin-C (TnC) is a glycoprotein that is highly expressed in inflammatory conditions of the CNS...

Depression is a mental disorder that results from changes in the central nervous system (CNS) that may result from immunological abnormalities. According to the World Health Organization, major depression will become the leading cause of disability worldwide. Accumulating evidence has indicated the existence of reciprocal communication pathways between nervous, endocrine and immune systems. The...

Both the safety and effectiveness of intrathecal tigecycline (TGC) for treatment infections central nervous system (CNS) are discussed using clinical findings from a study recent patient who came to our attention, along with literature review. Although penetration into CNS is low (approximately 11%), intraventricular TGC could help treat patients severe post- neurosurgical infections. The use m...

Neuroepigenetics is a new emerging field, mainly focusing on epigenetic mechanism study of the central nervous system (CNS). New discoveries show that the CNS-related behaviors, CNS disorders, neural plasticity, neurotoxicity, drug addiction and other neurological disorders are related to the underlying epigenetic mechanisms. Moreover, the development and the function of the human nervous syste...

sarcoidosis is a multisystem noncaseating granulomatous disease with a propensity for lung, eye, and skin which recently have been proposed that mycobacterium tuberculosis may contribute in its pathogenesis, and rarely involves central nervous system (cns). despite cd4+ lymphocytopenia, sarcoidosis by itself does not increase risk of opportunistic infections other than cryptococcosis.nonetheles...

Bone morphogenetic protein 9 (BMP9), also known as growth differentiation factor 2 (GDF2), is a member of the transforming ? (TGF ?) superfamily. Although BMP9 plays pivotal roles during development, including angiogenesis, hematopoiesis, hepatogenesis, osteogenesis, and glucose metabolism, little information available for expression in central nervous system (CNS). We, thus, investigated adult...

Gliomas are the most common neoplastic tumours of the central nervous system. The aim of the study was to evaluate the proliferative activity of chosen types of gliomas and to analyse their correlation with histological type, malignancy grade, location, size and clinical symptoms. The study involved patients with astrocytoma, anaplastic astrocytoma, glioblastoma, oligodendroglioma, anaplastic o...