Objective(s): Parkinson’s disease (PD) is characterized by motor and cognitive dysfunctions. The progressive degeneration of dopamine-producing neurons that are present in the substantia nigra pars compacta (SNpc) has been the main focus of study and PD therapies since ages.Materials and Methods: In this manuscript, a systematic revision...

To survive in natural waters, bacteria must respond to variety of environmental factors. Flexibacter survival in the aquatic environment is influenced by number of parameters, such as temperature, heavy metal concentration and oxidation. Here we investigate the influence of these factors on the survival of Flexibacter chinensis in starvation medium. Our data shows that different concentrations ...

Introduction: The use of cell phones is widespread and there are public concerns regarding its possible deleterious effects on human health especially on the pregnancy outcomes. In this study, structural changes of the placenta after applying the cell phone radiation were examined in the mice model.   Materials and methods: For this work, 40 pregnant Balb/C mice were randomly allocated to ...

An unbounded number of events exist beneath the intricacy of each particular hematologic malignancy, prompting the tumor cells into an unrestrained proliferation and invasion. Aberrant expression of cyclin-dependent kinases (CDKs) is one of these events which disrupts regulation of cell cycle and subsequently, results in cancer progression. In this study, we surveyed the repressive impact of mu...

Background: Pigment epithelium-derived factor (PEDF) is regarded as a multifunctional protein possessing neurotrophic and neuroprotective properties. PEDF has a very short half-life, and it would require multiple injections to maintain a therapeutically relevant level without a delivery system. However, multiple injections are prone to cause local damage or infection. To overcome this, we chose...

introduction: hyperthermia created by microwave (mw), infrared, ultrasound and other methods, is often utilized as an adjuvant to sensitize cancer cells to the effects of chemotherapy and radiation therapy. we investigated the efficacy of hyperthermia using mw in synergy with chemotherapy in the presence and absence and gold nanoparticles (gnps). material and methods: after culturing and prolif...