Our knowledge of how individual cells self-organize to form complex multicellular systems is being revolutionized by a data outburst, coming from high-throughput experimental breakthroughs such as single-cell RNA sequencing and spatially resolved single-molecule FISH. This information starting be leveraged machine-learning approaches that are helping us establish census timeline cell types in d...

800x600 unfortunately, at present, degenerative retinal diseases such as retinitis pigmentosa remains untreatable. patients with these conditions suffer progressive visual decline resulting from continuing loss of photoreceptor cells and outer nuclear layers. however, stem cell therapy is a promising approach to restore visual function in eyes with degenerative retinal diseases such as retiniti...

Nanoparticles are unique that enable many promising medical and technological applications intheir physical, and chemical properties. It is widely accepted that nanoparticles should bethoroughly tested for health nanotoxicity, but a moderate risk analysis is currently prevented by arevealing absence of mechanistic knowledge of nanoparticle toxicity. The purpose of this study<b...

A Product of Experts (PoE) model is a probabilistic model which combines a number of individual component models by multiplying their probabilities. A typical PoE model is an exponential family Harmonious introduced by Welling et al. In this paper, we apply a hierarchical PoE model, Complex-Cell Model (CCM), to image retrival and compare the performance with a kind of standard harmonious model,...

the aberrant assembly of proteins into fibrillar aggregates is accused to be the primary cause of pathogenesis of neurodegenerative diseases. but the structural determinants of protein fibrils that are responsible for cell dysfunction are not yet clear. in the current study, cell culture, spectroscopic techniques as well as theoretical and structural investigations were used to determine the ab...