introduction: acute leukemia is the most common malignancy in children and acute lymphoblastic leukemia (all) accounts for 75% of acute leukemia cases. new treatment protocols have resulted in complete remission rates up to nearly 100% in children with acute lymphoblastic leukemia. today, one of the most important prognostic factors in acute lymphoblastic leukemia is intensity of the treatment....

Adult T-cell Leukemia/Lymphoma (ATLL) is a rare aggressive malignancy associated with human leukemia virus type 1 (HTLV-1) infection. However, little known about the underlying activated molecular pathways at single cell level. Moreover, intercellular communications between tumor microenvironment (TME) and cells in this are currently unknown. Difficulties harvesting fresh tissue clinical settin...

background: interaction between killer cell immunoglobulin-like receptors (kir) and human leukocyte antigen (hla) class i molecules is important for regulation of natural killer (nk) cell function. objective: the aim of this study was to investigate the impact of compound kir-hla genotype on susceptibility to acute leukemia. methods: cohorts of iranian patients with acute myeloid leukemia (aml;...

Abstract Studies of acute myeloid leukemia rely on DNA sequencing and immunophenotyping by flow cytometry as primary tools for disease characterization. However, tumor heterogeneity complicates integration variants immunophenotypes from separate measurements. Here we introduce DAb-seq, a technology simultaneous capture genotype cell surface phenotype single cells at high throughput, enabling di...

regulation of normal cell growth and turnover is balanced between cell pro¬liferation, cell differentiation and apoptosis. a disruption of this balance is thought to be an important event leading to carcinogenesis .one of the effector molecules in apoptosis is fas antigen . cross-linking of fas by its ligand (fas l) or agonistic anti fas antibodies induces apoptosis of cells expressing fas on t...

CAR T cell therapy is a promising immunotherapy that can target and eradicate leukemia cells with high specificity. While CD19, CD20, CD22 have shown impressive responses in ALL patients

Herein we describe a case of intraocular melanoma in a17-year old leukemic patient.  The history, histological findings of the enucleated eye, blood and bone marrow of the patient were investigated. The enucleated eye contained epitheloid cell type melanoma instead of leukemic cell infiltration.  We conclude that intraocular malignant melanoma can occur in acute lymphoblastic leukemia.

Abstract Resistance remains the major clinical challenge for therapy of Philadelphia chromosome–positive (Ph+) leukemia. With exception ponatinib, all approved tyrosine kinase inhibitors (TKIs) are unable to inhibit common “gatekeeper” mutation T315I. Here we investigated therapeutic potential crizotinib, a TKI targeting ALK and ROS1 in non-small cell lung cancer patients, which inhibited also ...

Background: Previous studies have pointed to the major role of viruses in pathogenesis cancers, especially lymphoproliferative cancers. Objectives: The current study investigated relationship between recent Human Herpesvirus Type 6 (HHV6) infection and childhood leukemia-lymphoma syndrome. Methods: From January 2011 December 2012, we entered every new case acute lymphoblastic leukemia, non-Hodg...