diffuse large b cell lymphoma is the most common type of non-hodgkin's lymphoma, representing nearly one-third of all cases. any organ can be involved, making a diagnostic biopsy imperative. when the lungs are the involved organs, it is called primary pulmonary lymphoma (ppl). hereby, we present a case of primary pulmonary lymphoma (ppl) that demonstrated a single large mass on chest ct and had...

T regulatory (T(R)) cells suppress T-cell responses that are critical in the development of chronic viral infection and associated malignancies. Programmed death-1 (PD-1) also has a pivotal role in regulation of T-cell functions during chronic viral infection. To examine the role of PD-1 pathway in regulating T(R)-cell functions that inhibit T-cell responses during virus-associated malignancy, ...

monary mucosa-associated lymphoid tissue lymphoma successfully treated with clarithromycin. Chest 2010;138:730-3. 2. Ohe M, Hashino S. A case of follicular B-cell lymphoma treated using clarithromycin. Korean J Hematol 2011;46:203-6. 3. Ohe M, Hashino S, Hattori A. Successful treatment of diffuse large B-cell lymphoma with clarithromycin and prednisolone. Korean J Hematol 2012;47:293-7. 4. Ohe ...

Plasma thymidine kinase (TK) activity was evaluated as a plasma marker for canine lymphoma and leukemia. A tentative "cut-off" value was set at 6.0 U/l as the upper level of plasma TK based on the mean + 2SD of plasma TK activity in 13 clinically healthy dogs. The levels of plasma TK activity in all of the 20 dogs with lymphoma and leukemia were higher than the cut-off value, whereas those in d...

Soluble tumor-associated antigens and histocompatibility antigens were detected in sera of A/J mice bearing a spontaneous lymphoma (Ll l l7) by the inhibition of the cytotoxicity of rabbit anti-Ll l l7 serum and of alloantisera to normal A/J antigens, respectively; the rabbit antiserum was rendered specific for lymphoma antigens by extensive absorption with normal A/J cells and alloantisera wer...

The role of lymphocytes in eliminating lymphoma cells is based on the interaction between activating receptors on lymphocytes and target surface ligands on lymphoma cells. Stress-related immunity can be triggered both in Hodgkin's (HL) and non-Hodgkin lymphomas (NHL), through the activation of the NKG2D receptor on CD8+ T and gammadelta T lymphocytes, by NKG2D-ligands (NKG2D-L), as the MHC clas...

BACKGROUND Follicular lymphoma, the neoplastic counterpart of germinal center B cells, typically recapitulates a follicular architecture. Several observations point to the crucial role of the cellular microenvironment in the development and/or progression of follicular lymphoma cells in vivo. The aim of our study was to characterize the spontaneous apoptosis of follicular lymphoma cells in vitr...