Clinical Actinobacillus actinomycetemcomitans produces cytolethal distending toxin (CDT) with titers ranging from 10(2) to 10(8) U/mg. Single nucleotide polymorphism analysis of the cdt gene in clinical isolates identified a variation of a single amino acid at residue 281 of CdtB, which significantly affected CDT toxicity by modulating the chromatin-degrading activity of CdtB.

Two rare copper complexes, a tri-alkene adduct [Cu(ttt-cdt)(FSbF(5))] and a non-classical carbon monoxide complex [Cu(ttt-cdt)(CO)][SbF(6)] with a high CO stretching frequency ([small nu, Greek, macron](CO) = 2160 cm(-1)), have been isolated using trans,trans,trans-1,5,9-cyclododecatriene (ttt-cdt) ligand.

There is limited data regarding the cognitive profile from screening tests of older adults with bipolar disorder (BD) with dementia. Objective To investigate the Clock Drawing Test (CDT) among older adults with BD with and without Alzheimer's disease (AD). Method 209 older adults (79 with BD without dementia and 70 controls; 60 with AD, being 27 with BD) were included to evaluate the performanc...

This work presents an algorithm that given a generalized planar graph obtains its constrained Delaunay triangulation (CDT). The proposed method, which follows the general approach of [3], works incrementally based on two improved procedures. The first improvement gives a procedure that inserts a new point in a CDT; the second one is an algorithm that enforces a new constraining edge in a CDT. I...

We introduce the restricted constrained Delaunay triangulation (restricted CDT). The restricted CDT generalizes the restricted Delaunay triangulation, allowing us to define a triangulation of a surface that includes a set of constraining segments. Under certain sampling conditions, the restricted CDT includes every constrained segment and suggests an algorithm that produces a triangulation of t...

The cytolethal distending toxin (CDT) of the oral pathogen Aggregatibacter actinomycetemcomitans induces cell cycle arrest and apoptosis in various cell types. Western analysis, pharmacological inhibition and siRNA silencing were performed in human immortalized gingival keratinocytes (HIGK) to dissect the functional role of the ataxia telangiectasia mutated (ATM) pathway in the signal transduct...

The Clock Drawing Test (CDT) is an inexpensive, fast and easily administered measure of cognitive function, especially in the elderly. This instrument is a popular clinical tool widely used in screening for cognitive disorders and dementia. The CDT can be applied in different ways and scoring procedures also vary. Objective The aims of this study were to analyze the performance of elderly on ...

In this paper we consider the problem of minimizing a nonconvex quadratic function, subject to two quadratic inequality constraints. As an application, such quadratic program plays an important role in the trust region method for nonlinear optimization; such problem is known as the CDT subproblem in the literature. The Lagrangian dual of the CDT subproblem is a Semidefinite Program (SDP), hence...

BACKGROUND There is little data comparing catheter-directed thrombolysis (CDT) via small saphenous veins vs. systematic thrombolysis on complications and efficacy in acute deep venous thrombosis patients. The aim of our study was to compare the efficacy and safety of CDT via the small saphenous veins with systematic thrombolysis for patients with acute deep venous thrombosis (DVT). MATERIAL AND...