نتایج جستجو برای: cdc25a

تعداد نتایج: 514  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2004
Yiling Hong Peter J Stambrook

Response to DNA damage and cell-cycle regulation differ markedly between embryonic stem (ES) cells and somatic cells. ES cells require exquisitely sensitive mechanisms to maintain genomic integrity and do so, in part, by suppressing spontaneous mutation. Spontaneous mutation frequency in somatic cells is approximately 10(-4) compared with 10(-6) for ES cells. ES cells also lack a G(1) checkpoin...

Journal: :medical laboratory journal 0
seyed mostafa mir department of clinical biochemistry, school of medicine, babol university of medical sciences, babol, iran esmaeil samadian laboratory sciences research center, golestan university of medical sciences, gorgan, iran sahar alijanpour department of medical genetics, faculty of advanced medical technologies, golestan university of medical sciences, gorgan, iran alireza khoshbin khoshnazar department of clinical biochemistry, school of medicine, golestan university of medical sciences, gorgan, iran hamid haghighatfard department of medical biotechnology, faculty of advanced medical technologies, golestan university of medical sciences, gorgan, iran seyed hossein sadeghi department of medical genetics, school of medicine, shahid beheshti university of medical sciences, tehran, iran

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Journal: :Journal of Experimental & Clinical Cancer Research 2021

Abstract Background Long noncoding RNAs (lncRNAs) contribute to multiple biological processes in human glioblastoma (GBM). However, identifying a specific lncRNA target remains challenge. In this study, bioinformatics methods and competing endogenous RNA (ceRNA) network regulatory rules were used identify GBM-related lncRNAs revealed that OXCT1 antisense 1 (OXCT1-AS1) is potential therapeutic f...

Journal: :The Journal of biological chemistry 2004
Daniel F McCain Li Wu Peter Nickel Matthias U Kassack Annett Kreimeyer Antonio Gagliardi Delwood C Collins Zhong-Yin Zhang

Protein-tyrosine phosphatases (PTPs) are important signaling enzymes that have emerged within the last decade as a new class of drug targets. It has previously been shown that suramin is a potent, reversible, and competitive inhibitor of PTP1B and Yersinia PTP (YopH). We therefore screened 45 suramin analogs against a panel of seven PTPs, including PTP1B, YopH, CD45, Cdc25A, VHR, PTPalpha, and ...

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