Background and Aim: Intrahepatic cholestasis of pregnancy (ICP) is associated with raised liver enzymes, pruritus elevated fasting total bile acids (TBA) may lead to adverse perinatal outcomes such as preterm birth, meconium-stained liquor, stillbirth, foetal growth restriction etc. The change in inflammatory profile ICP association TBA not known. Methods: Patients (aged >21) confirmed diagnosi...

current mainstay of treatment for human immunodeficiency virus (hiv)-infected patients is highly active antiretroviral therapy (haart) but little is known about the long-term clinical outcome for hiv-infected patients who have received haart. determining factors associated with longterm survival in the course of treatment may allow modification to be made for patients who are at a greater risk ...

cytokine production  in response to allergens may influence the development of atopy- predisposing immune responses, initializing the  early programming of  allergy and  asthma. vitamin d  intake  may be  protective  due  to  its  immunoregulatory properties,  that  may contribute  to  influence the expression of  the atopic phenotype  initiated in early life. the objective of our study was to ...

Aging is associated with remodeling of the immune system, contributing to increased incidence of infections, autoimmune diseases, and cancer among the elderly. Alterations in several signal transduction pathways have been reported to play an important role in immunosenescence. We show that peripheral blood leukocytes obtained from old donors (> or =65 years) have a significantly reduced express...

Interleukin-10 (IL-10)–treated dendritic cells (DCs) induce an alloantigenor peptide-specific anergy in various CD41 and CD81 T-cell populations. In the present study, we analyzed whether these anergic T cells are able to regulate antigenspecific immunity. Coculture experiments revealed that alloantigen-specific anergic CD41 and CD81 T cells suppressed proliferation of syngeneic T cells in a do...

background: the aim of preliminary study was determined development process status of t-cell population lymphocytes in ukrainian children after 22 years from chernobyl accident for next feasibility study. material and method: 150 participants aged 6 to 16 years are included in three groups: group i (n=65), 30 to 60 km from center accident at zone 3th, group ii (n=65) 60 to 90 km from same locat...

Chronic, excessive exposure to solar ultraviolet radiation is the major causative agent for cutaneous squamous cell carcinomas. Mutations in p53 are essential these cancers develop. UV also immunosuppressive and an additional requirement UV-induced carcinomas The objective of this study determine whether a mediated immune response develops mutations p53. To accomplish our objective, we used imm...