Analysis of rates from disease registers are often reported inadequately because of too coarse tabulation of data and because of confusion about the mechanics of the age-period-cohort model used for analysis. Rates should be considered as observations in a Lexis diagram, and tabulation a necessary reduction of data, which should be as small as possible, and age, period and cohort should be trea...

OBJECTIVE Tort reform may affect health insurance premiums both by reducing medical malpractice premiums and by reducing the extent of defensive medicine. The objective of this study is to estimate the effects of noneconomic damage caps on the premiums for employer-sponsored health insurance. DATA SOURCES/STUDY SETTING Employer premium data and plan/establishment characteristics were obtained...

T-cell mediated cytotoxic responses to H-Y antigen require co-recognition of H-Y and H-2 gene products. F1 mael stimulating cells and target cells express H-Y antigen in association with both parental H-2 haplotypes. However, F1 females primed in vivo and challenged in vitro with F1 male cells lyse male target cells of F1 and only one parental H-2 haplotype. Thus, (CBA X B10)F1 females sensitiz...