OBJECTIVES The aim of this study was to compare the clinical effective rates of high-dose immunosuppressive therapy combined with cord blood infusion (IS + CBI) and non-myeloablative peripheral blood stem cell transplantation (NSCT) for severe aplastic anemia (SAA). PATIENTS AND METHODS Human leukocyte antigen (HLA)-mismatched patients received immunosuppressive therapy combined with IS + CBI...

Candida bloodstream infections (CBI) are one of the most common nosocomial infections globally, and they account for a high mortality rate. The increasing global prevalence of drug-resistant Candida strains has also been posing a challenge to clinicians. In this study, we comprehensively evaluated the biofilm formation and production of hemolysin and proteinase of 63 CBI isolates derived from a...

In the last three decades, legal delegation of monetary policy to independent central banks (CBI) has achieved status a global norm good governance. The recent backlash against this independence is an important but understudied trend. Our article analyzes potential for reversals with focus on Latin America where CBI was effective in maintaining price stability, placed constraints governments. W...

Designers of computer-based instruction (CBI) and web-based instruction (WBI) need approaches that support the creation of products that are effective, efficient, and appealing. In order to achieve these product qualities, early CBI researchers pursued goals of adaptivity, generativity, and scalability (Stolurow, 1969; Suppes, 1969). Researchers also felt that computerizing instruction would al...

An in vitro assay for measurement of gastric juice intrinsic factor (IF) was developed based on the ability of the cobinamide (Cbi) [(CN, OH) Cbi] to bind to the gastric juice R-type binders of cobalamin (Cbl) and not to the IF binder. Subsequently added radioactive Cbl, CN-[57Co] Cbl, binds only to the IF binders and allows for direct measurement of this Cbl binding protein. This Cbi blocking ...

Open source software is an attractive target when developing and evaluating software defect detection tools. This position paper discusses some of the benefits and challenges I have encountered as a researcher interacting with the open source community. The Cooperative Bug Isolation Project (CBI) explores ways to identify and fix bugs in widely deployed software. We use a mix of lightweight ins...

Alkylating agents are generally highly reactive with DNA but demonstrate limited DNA sequence selectivity. In contrast, synthetic pyrrole-imidazole polyamides recognize specific DNA sequences with high affinity but are unable to permanently damage DNA. An eight-ring hairpin polyamide conjugated to the alkylating moiety cyclopropylpyrroloindole, related to the natural product CC-1065, affords a ...

A technique-:was developed to facilitate creating computer-based instruction (CBI) with a Minimum of effort On the part of the-author/coder, and 'the feasibility of using a structure which puts control of the lesson strategy into the hands of the_student learner was investigated. A model which relieve* tire author' of CBI strategy selection was developed for the PLATO IV sySted and was testedin...

P rograms for computcr-based instruction (CBI) have come a long way in the last two decades. They are available today in a variety of sophisticated shapes and sizes, and show few traces of their origins in B. F. Skinner's modest, fill-in-the-blanks teaching machines. The programs tutor and drill students, diagnose learning difficulties, prescribe remedies for problems, keep records of student p...