Nine new causative mutations and seven previously characterised mutations of the APC gene of patients with familial adenomatous polyposis (FAP) were analysed for any genotype-phenotype correlations. The only clear genotype-phenotype correlation found was between the position of the mutation site and the presence or absence of congenital hypertrophy of the retinal pigment epithelium (CHRPE). A m...

Overload of neonatal and adult cardiomyocytes and multicellular myocardial preparations, which include whole hearts, are accompanied by an enhanced activity of the Na /H exchanger 1 (NHE-1). Exogenous administration of prohypertrophic agents such as angiotensin II (Ang II), endothelin-1 (ET-1), and 1-adrenergic agonists also stimulates NHE-1 activity, which leads to an increased concentration o...

The Enterobacterial repetitive intergenic consensus (ERIC) marker was used to analyze the genetic variability of Mycosphaerella fijiensis, the causative agent of Black Sigatoka disease in banana plants. A total of 123 isolates were used, which were divided into populations based on their original hosts and collection sites in Brazil. A total of 9 loci were amplified, 77.8% of which were found t...

Eleven flayones, including cochliophi]in A and a chromone, were chemically prepared to determine the attracting activity for zoospores of Aphanoayees eochtioitles, a causative fungus ef spinach root rot. Analyses of the structure-activity relationship of each revea]ed a significant correlation between the zoospore attracting a ¢ tivity and the A-ring oxygenation at C-5 and C-7 in the fiavone sk...

In the summary of product characteristics of infliximab (IFX), psychiatric side effects are reported to be rare, and in literature only limited data exist. This report presents a case of a patient with ulcerative colitis who developed a depression with psychotic symptoms during IFX therapy and made a suicide attempt 4 months after the initiation of therapy. Although the time between start of IF...

The most common causative mutation of Friedreich ataxia (FRDA) is the unstable hyperexpansion of an intronic GAA triplet repeat that impairs frataxin transcription. Using real time quantitative PCR, we showed that FRDA patients had residual levels of frataxin mRNA ranging between 13% and 30% and that FRDA carriers had about 40% of that of controls. Asymptomatic carriers also showed reduced frat...

Causatives are valence increasing operation where another core argument, a causal agent (causer), is added for expressing semantic or logical effect of causation on the non-causative verb. Causative construction comprises causer –the predicate cause, and causee – caused event (Payne 1997: 176). This paper described formation causatives in Maring, lesser-known Tibeto-Burman language spoken south...