Background: Acetaminophen (APAP), a common analgesic agent, is hepatotoxic in overdose. N-acetylcysteine (NAC), as an APAP antidote, shows anaphylactic reactions and has low efficacy poisoning high doses. Objectives: This study was designed to examine the hepatoprotective effect of biochanin A (BA) mice model acetaminophen-induced hepatotoxicity. Methods: To evaluate APAP-induced oxidative stre...

Catalase (CAT, OMIM: 115500) is an endogenous antioxidant enzyme and genetic variations in the regulatory regions of the CAT gene may alter the CAT enzyme activity and subsequently may alter the risk of oxidative stress related disease. In this study, potential influence(s) of the A-21T (rs7943316) and C-262T (rs1001179) genetic polymorphisms in the CAT promoter region, using the ALGGEN-PROMO.v...

introduction: in  major b -thalassemia impaired biosynthesis of beta hemoglobin leads to accumulation of unpaired alpha hemoglobin chain. an iron overload generates oxygen-free radicals which ultimately leads to tissue injury. the aim of this investigation was to evaluate serum antioxidants in patients with major b -thalassemia and those with minor thalassemia in comparison with respective age ...

The available evidence from in vitro and in vivo studies is deemed not sufficient to draw conclusions about the potential health effects of static magnetic field (SMF) exposure. Therefore, the aim of the present study was to determine the influence of static magnetic fields and phloretin on the redox homeostasis of human dermal fibroblasts. Control fibroblasts and fibroblasts treated with phlor...

BACKGROUND Since free radicals and antioxidant enzymes may play an important role in the development of diabetes, the present study was designed to assess the effect of supplementation with vitamins A, E and C and ω-3 fatty acids on catalase and superoxide dismutase activity in streptozotocin (STZ)-induced diabetic rats. METHODS A total of 64 male Wistar rats weighing 250 g were divided into ...

Reactive oxygen species (ROS) secreted by activated macrophages play a central role in causing rheumatoid arthritis, and therapeutics that can inhibit the production of ROS by macrophages have great clinical potential. Superoxide dismutase (SOD) and catalase (CAT) are two enzymes that scavenge ROS and have great potential for treating rheumatoid arthritis. However, clinical trials with these en...

This study investigated if the use of the pesticides cyprodinil and fludioxonil produced an inhibitory effect on the bovine liver catalase (CAT) activity. It was documented that the activity of the enzyme decreased with increasing concentrations of cyprodinil and fludioxonil from 0 to 500 ppm. At pesticide concentrations of 250 and 500 ppm, the activity of CAT remained unchanged and passed to a...

Cisplatin is a potent chemotherapeutic agent that is used to treat many human malignancies. Unfortunately, in addition to side effects such as ototoxicity, anaphylaxis, and bone marrow suppression, a significant percentage of patients receiving cisplatin develop severe nephrotoxicity. Mitochondrial dysfunction that is mediated via the generation of reactive oxygen species has been implicated in...

Crassostrea gigas D-shaped larvae were subjected to different conditions of temperature and salinity for 24 h and four biomarkers (acetylcholinesterase (AChE) activity, thiobarbituric acid reactive substances (TBARS) levels, glutathione S-transferase (GST) and catalase (CAT) activities) were measured. AChE activity decreased when salinity increased from 25 to 30 and 35 psu at 20 and 25 degrees ...

In this study, changes in malondialdehyde level (MDA), superoxide dismutase (SOD) and catalase (CAT) activity fish liver tissue were investigated by applying two doses of 2,4-dichlorophenoxyacetic acid (2,4-D) herbicide to Capoeta umbla for 72 hours. Changes MDA level, CAT SOD determined spectrophotometric methods. As a result the it was that there statistically significant increase C. exposed ...