umbelliprenin is a prenylated compound, which belongs to the class of sesquiterpene coumarins. it is extracted from dried roots of ferula szwitsiana collected from the mountains of golestan forest (golestan province, north of iran). induction of apoptosis in jurkat t-cll cells has been previously shown. in this study, effect of umbelliprenin on proapoptotic caspases (caspase-8 and -9) and antia...

ba ckground: liver cancer is one of the deadly cancers with high prevalence in the east asia. likewise most of diseases, herbs and herbal medicine could be an easy and cost effective tool in prevention and possible cancer treatment. the present study investigated the ability of orthosiphon stamineus benth decoction to protect liver against hepatocellular carcinoma in carcinogenesis-induced anim...

background and aims: the caspases are unique proteases that mediate the host cell apoptosis during viral infection. in this study, we identified the caspase cleavage motifs of h5n1 and h9n2 influenza viruses isolated during 1998-2012. materials and methods: amino acid sequences of the eleven proteins encoded by the viruses as the caspase substrates downloaded from ncbi. the caspase cleavage mot...

apoptosis is a complex network of biochemical and molecular pathway with fine regulatory mechanisms that control the death event during several pathological situations in multi cellular organisms. it is the part of normal development that occurs in a variety of diseases and is known as aberrant apoptosis. pancreatic β cell apoptosis is also a pathological feature which is common in both type 1 ...

Background: In this study, the protective effect of thymoquinone (TQ) and Nigella sativa seeds oil (NSO) was evaluated against oxidative damages induced by ethanol in rats. Methods: Animals were treated with ethanol 40% daily by gavages once a day for 4 weeks. NSO and TQ were injected intraperitoneal once a day for 4 weeks. The histopathological examination of liver, kidney, brain and heart was...

BACKGROUND Death of smooth muscle cells in the atherosclerotic plaques makes the plaques more prone to rupture, which can initiate an acute ischemic event. The development of atherosclerosis includes the migration of immune cells e.g. monocytes/macrophages and T lymphocytes into the lesions. Immune cells can release antimicrobial peptides. One of these, human cathelicidin antimicrobial peptide ...

The p53 mutant 143Ala is a human temperature-sensitive mutant with two conformational states. To definitively determine whether the Fas signal transduction pathway and the function of the pathway are dependent on p53 status, we have established stable transfectants of p53 mutant 143Ala in two human cancer cell lines: H1299 (lung cancer line) and PC-3 (prostate cancer line), the native state of ...

One important determinant of the speed and success of transition will be the efficiency of transformation and development of the infrastructure sectors. A great deal of attention has been paid to issues such as privatisation, restructuring, user prices, and terms of access in these sectors, regarding both developed and developing countries. Some issues regarding vertical restructuring are notab...