BACKGROUND Dental caries is the most common microbial disease affecting mankind. Caries risk assessment methods, identification of biomarkers and vaccine development strategies are being emphasized to control the incidence of the largely preventable disease. Pattern recognition receptors such as the toll like receptors (TLR) have been implicated as modulators of host-microbial interactions. Sol...

AIM The purpose of this retrospective case study is to describe the body mass index in a group of children, from 3 to 6 years old with ECC and a similar group of caries-free children. MATERIALS AND METHODS This case-control analysis involves two groups of children: the first was of 244 healthy children, 3 to 6 year-old and caries-free; the second was of 586 otherwise healthy children, same...

The aim of this study has been to evaluate the nature of changes in the quality of life in a population of teenagers with dental caries and their complications after oral caries elimination. The authors have examined and treated 112 teenagers, ages 12 to 17, with dental caries and complications, in the city of Moscow, Russia. A validated Child Perception Questionnaire (CPQ) was used to assess t...

OBJECTIVE To determine the clinical effectiveness of a community milk fluoridation programme. BASIC RESEARCH DESIGN Parallel arm 5-year cohort study, with final cross-sectional comparisons between groups. PARTICIPANTS 3-year-olds in 8 Bulgarian cities/towns entered the cohort study with random samples (n = 1,782) recruited at baseline in 2004. After 5 years in 2009 sub-samples (about 30%) o...

OBJECTIVES Diabetes mellitus is one of the most common chronic diseases in the general population. A study is made of the presence of caries in type 1 diabetic patients. The specific aim was to determine whether such patients present a greater incidence of dental caries than non-diabetic individuals. An evaluation was also made of the relationship of caries to salivary flow and to factors inher...

Scientific evidence of susceptibility to dental caries in the population with Down Syndrome (DS) is limited and conflicting, making it difficult to establish firm conclusions. The aim of this systematic review and meta-analysis was to obtain scientific evidence of the possible association between dental caries and individuals with DS, compared to individuals without DS (control). An electronic ...

Immunoglobulin A (IgA) and IgG antibodies against Streptococcus mutans K1R and 10449 were measured in serum and in stimulated whole saliva from two groups of naval recruits, representing high or low caries susceptibility. The antibody assays were performed by using the enzyme-linked immunosorbent assay, and the results were expressed by a method able to estimate the amount of high-avidity and t...

The caries-inducing activity of palatinose (isomaltulose, alpha-D-glucopyranosyl-1,6-fructose) was examined in in vitro and in vivo experiments, comparing it with other carbohydrates. When Streptococcus mutans was successively subcultured in a broth medium containing 1% palatinose, the strains belonging to serotype a, d, or g did not ferment palatinose, whereas the strains belonging to serotype...

BACKGROUND The aim of this longitudinal study was to compare caries incidence in sound approximal surfaces adjacent to newly placed composite restorations with the caries incidence in corresponding surfaces in contralateral teeth without any restorations in contact; and to assess risk factors for dentine caries development on adjacent and control surfaces. METHODS Data from a practice-based s...

PURPOSE The purpose of the research is to assess the state of dentition and oral hygiene in 16-25-year-old young people with mild and moderate mental disability in comparison with a control group of healthy young people at the same age. MATERIAL AND METHODS The research was carried out in a special School and Tutelary Centre in Lublin. A group of 144 young people aged 16-25 with mild and mode...