Bacterial enzymes have long been considered solely accountable for the degradation of the dentin matrix during the carious process. However, the emerging literature suggests that host-derived enzymes, and in particular the matrix metalloproteinases (MMPs) contained in dentin and saliva can play a major role in this process by their ability to degrade the dentin matrix from within. These finding...

The exact mechanisms and enzymes involved in caries progression are largely unclear. Apoptosis plays a key role in dentin remodelling related to damage repair; however, it is unclear whether apoptosis in decayed teeth is activated through the extrinsic or the intrinsic pathway. This ex vivo immunohistochemical study explored the localization of TRAIL, DR5, Bcl-2 and Bax, the main proteins invol...

Tratamento Restaurador Atraumático, conhecido como ART (Atraumatic Restorative Treatment), trata-se de uma técnica que utiliza apenas escavadores e curetas manuais para realizar a remoção do tecido cariado. Posteriormente, é aplicado um material restaurador adesivo, o cimento ionômero vidro (CIV) apresenta vantagem liberação flúor. Essa seletiva cariado, removendo infectado mantém afetado. Com ...

The recording of multiple interval-censored failure times is common in dental research. Modeling multilevel data has been a difficult task. This paper aims to use the Bayesian approach to analyze a set of multilevel clustered interval-censored data from a clinical study to investigate the effectiveness of silver diamine fluoride and sodium fluoride varnish in arresting active dentin caries in C...

This historical treatise follows the documented timeline of tooth decay into today's understanding, treatment, and teaching of caries biology. Caries has been attributed to many different causes for several millennia, however, only since the late 1900s has research revealed its complex multifactorial nature. European writers of the 1600s to 1700s held views that general health, mechanical injur...

This study investigated the influence of a papain-based gel (Papacárie) for chemo-mechanical caries removal on bond strength to dentin. Human molars were assigned to the following groups: Group 1: sound teeth were flattened to expose dentin; Group 2: after flattening of surfaces, the papain-based gel was applied on the sound dentin; Group 3: overlying enamel from carious teeth was removed and m...

INTRODUCTION The pattern of development of carious lesions has changed. The carious lesion has been progressive and reaches the dentin without showing alterations in the clinical aspects. OBJECTIVES To determine the prevalence of caries in 12-year-old students in the city of Franca - São Paulo, Brazil, during the year of 2003, and to evaluate the additional value of bitewing radiograph to det...

AIM This review aims to summarise our understanding of the destructive role of acid environment and metalloproteinases in dentin caries progression using a review process. METHOD The acids resulting from consumption of sugars by acidogenic and aciduric bacteria can cause demineralisation of the tooth surface, but are not able to cause caries-like lesions. The appearance of such lesions requir...

AIM A new and innovative therapeutic concept using a light-induced fluorescence evaluator for diagnosis and treatment (LIFEDT) of dental caries based on the imaging and autofluorescence of dental tissues is proposed. The aims of this series of in vivo experiments are to compare and analyze the brightness variations of sound dentin and active and arrested carious dentin illuminated with an intra...

Fluoride-releasing materials can be expected to inhibit secondary caries and enhance remineralization of decalcified dentin underneath restorations. The aim of this study was to evaluate the inhibitory effect on secondary caries and remineralization of decalcified dentin by fluoride-releasing adhesives. Two commercial fluoride-releasing adhesives, Reactmer bond (RB, Shofu) and One-up bond F (OB...