background: tricyclic antidepressants (tcas) poisoning is the most common poisoning in the poisoning emergency department of noor hospital, isfahan, iran. the objective of this study was to compare qrs interval duration with ravr³3mm and r/savr³ 0.7 in predicting: serious complications of acute tca toxicity. methods and materials: this study was descriptive – analytic and prospective cohort. tc...

Although doxorubicin (DOX) is a very effective antineoplastic agent, its clinical use is limited by a dose-dependent, persistent and cumulative cardiotoxicity, whose mechanism remains to be elucidated. Previous works in animal models have failed to use a multi-organ approach to demonstrate that DOX-associated toxicity is selective to the cardiac tissue. In this context, the present work aims to...

The acute toxic effect of different crude oils (heavy crude oil and bonny light crude oil) on embryos of marine medaka Oryzias melastigma was measured and evaluated by exposure to the water-accommodated fraction (WAF) in the present study. The cardiac function of medaka embryos was used as target organ of ecotoxicological effect induced by oil exposure. Results showed that the developing marine...

Adriamycin (ADR) is a potent anticancer drug known to cause severe cardiac toxicity. Although ADR generates free radicals, the role of free radicals in the development of cardiac toxicity and the intracellular target for ADR-induced cardiac toxicity are still not well understood. We produced three transgenic mice lines expressing increased levels of human manganese superoxide dismutase (MnSOD),...

PURPOSE OF REVIEW Laboratory studies and clinical reports have led to the acceptance of lipid emulsion as an effective treatment of local anesthetic-induced cardiac arrest. This review discusses subsequent clinical reports, relevant laboratory studies and topics for further research. RECENT FINDINGS Case reports have confirmed the efficacy of lipid resuscitation for local anesthetic systemic ...

in iranian folk medicine, especially in west of the country, the aromatic water of rheum ribes has been used for several purposes such as fever reduction.  despite the widespread use of this plant as food or as a medicinal plant, there is still lack of information on its toxicity profile.                                                                in the present study we aimed to evaluate th...

Several species of the genus Veratrum that produce steroid alkaloids are commonly used to treat pain and hypertension in China and Europe. However, Veratrum alkaloids (VAs) induce serious cardiovascular toxicity. In China, Veratrum treatment often leads to many side effects and even causes the death of patients, but the pathophysiological mechanisms under these adverse effects are not clear. He...

a Cardiovascular Disease Service, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, MD, United States b Pulmonary Disease and Critical Care Service, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, MD, United States c Internal Medicine Service, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, MD, United ...

5-FU was discontinued. Previous reports have identified angina1 symptoms as a rare symptom of 5-FU cardiac toxicity.1-5 Some of these patients had also undergone irradiation4 of the left ventricle or had coronary artery disease.‘s3 Underwood et a1.6 suggested coronary artery spasm as a possible mechanism of toxicity. Other proposed mechanisms have included an autoimmune response and inflammator...