The article provides an overview of key studies on vagus nerve stimulation. stimulation method affects the fibers internal and external plexuses, enhancing parasympathetic effect. positive therapeutic effect has been achieved in various experimental clinical treatment neurological cardiac diseases, metabolic syndrome, obesity. It shown that reduces epileptic seizures frequency, arrhythmias, is ...

It has been suggested that nitric oxide (NO) is a key modulator of both baroreceptor and exercise pressor reflex afferent signals processed within the nucleus tractus solitarius (NTS). However, studies investigating the independent effects of NO within the NTS on the function of each reflex have produced inconsistent results. To address these concerns, the effects of microdialyzing 10 mM L-argi...

The concept of depressor reflexes originating in the heart was introduced by von Bezold in 1867 and was later revived by Jarisch. The Bezold-Jarisch reflex originates in cardiac sensory receptors with nonmyelinated vagal afferent pathways. The left ventricle, particularly the inferoposterior wall, is a principal location for these sensory receptors. Stimulation of these inhibitory cardiac recep...

Veratrum alkaloids injected into the coronary circulation stimulate myocardial receptors to produce reflex bradycardia and arterial hypotension (the Bezold-Jarisch reflex). This study investigated the hypothesis that parasympathetic coronary vasodilation occurs as part of the Bezold-Jarisch reflex. Blood flow in the circumflex coronary artery was measured in chloralose-anesthetized, closed-ches...

Hines, Tina, and William A. Herzer. Effect of cardiac receptor stimulation on renal vascular resistance in the pregnant rat. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 278: R171–R178, 2000.—Stimulation of cardiac receptors (CR) evokes blunted reflex reductions in mean arterial pressure (MAP) in pregnant compared with virgin rats. Because CR-mediated sympathoinhibition has preferentia...

We have developed a chronic technique to isolate the carotid sinus baroreceptor region in the conscious rat model. Our technique, when used in conjunction with other methods, allows for the study of the control of arterial pressure, heart rate, and cardiac output by the carotid sinus baroreceptor reflex in conscious, unrestrained rats. The performance of our technique was evaluated in two strai...

African Americans have a greater prevalence of hypertension and diabetes compared with white Americans, and both autonomic dysregulation and inflammation have been implicated in the etiology of these disease states. The purpose of this study was to examine the cardiac autonomic and systemic inflammatory response to resistance training in young African-American and white men. Linear (time and fr...

Syncope caused by cardiac asystole during dobutamine stress echocardiography occurred in a 60 year old woman presenting with chest pain and a non-diagnostic exercise test. Cardiac asystole was not associated with myocardial ischemia and was attributed to a powerful cardioinhibitory vagal reflex elicited by the stimulation by the drug of cardiac and aortic mechanoreceptors. Cardiac asystole was ...

A patient with transient, intermittent, complete heart block had periods of asystole, accompanied by syncope, whenever his cardiac rhythm shifted spontaneously from regular sinus rhythm to complete auriculoventricular dissociation. Similar clinical and electrocardiographic findings were produced by carotid sinus pressure when there was regular sinus rhythm. During the periods of heart block car...

vasovagal syncope or neurocardiogenic syncope refers to the loss of consciousness that occurs secondary to hypotension resulting in reduced blood supply to the brain. it is the most common form of unexplained syncope (50-60%) in the outpatient setting. Bradycardia and vasodilation are the primary causes of this hypotension. fear, pain, dehydration, alcohol consumption, anxiety, tight clothing a...