objective(s):higher cellular reactive oxygen species (ros) levels is important in reducing cellular energy charge (ec) by increasing the levels of key metabolic protein, and nitrosative modifications, and have been shown to damage the cardiac tissue of diabetic mice. however, the relation between energy production and heart function is unclear. materials and methods:streptozotocin (stz, 150 mg/...

We studied the protective effect of stromal cell-derived factor-1β (SDF-1β) on cardiac cells from lipotoxicity in vitro and diabetes in vivo. Exposure of cardiac cells to palmitate increased apoptosis by activating NADPH oxidase (NOX)-associated nitrosative stress and endoplasmic reticulum (ER) stress, which was abolished by pretreatment with SDF-1β via upregulation of AMP-activated protein kin...

brachial plexus injury (bpi) is an uncommon complication of median sternotomy capable of causing a permanent or transitory sensitivity and/or motor function impairment in the upper limbs. during a cardiac surgery through sternotomy, for the assessment of the thoracic cage configuration and the site of mediastinal structures, a broader surgical field may be required. if the sternal retractors ar...

to date, stem cell therapy is a novel treatment method especially in irreversible end organ damage. we present a case of a 21-yr-old man, who admitted in sina hospital, tehran university of medical sciences, iran with open left femur fracture following car accident. developing fat emboli syndrome led to cardiac arrest. despite of efforts to optimize supportive care and neuroprotective strategie...

BACKGROUND Alcohol-induced hyperlipidemia is positively correlated with cardiovascular diseases. Several herbal extracts have been reported to protect the cardiac injury and suppress the hyperlipidemia. However, the effect of ginger extracts on alcohol-induced hyperlipidemia and associated myocardial damage remains unclear. OBJECTIVE This study investigated the cardio-protective properties of...

Methamphetamine (MET) is a stimulant and one of the most abused drugs in worldwide. MET could cause several organ toxicity such as cardiotoxicity. Oxidative stress has been proposed as the main mechanism for MET toxicity. Propofol as a sedative-hypnotic agent has antioxidant property. In this study, we used propofol for attenuating of MET-induced cardiotoxicity in rats. The groups (six rats in ...

Severe aortic stenosis (AS) results in cardiac damages, such as left ventricular hypertrophy, atrial enlargement, pulmonary pressure elevation and advanced stage, right damage. Généreux colleagues proposed a staging classification based on these extra-valvular damages 2017, with increasing stage representing more While regression of is expected following valve replacement, the reversal damage t...

Six examples of cardiac damage secondary to non-penetrating trauma in road accidents are described. In all six cases the lesion was not recognised at the time of the accident but became clinically important two days to 17 years later. As the patients were young or had unusual lesions, the damage could be attributed to the accident. In older patients with common cardiac problems the trauma might...