Background: Symptomatic knee osteoarthritis (OA) is typically treated with hyaluronan-based intra-articular injections. Advanced OA patients are often unresponsive to hyaluronan. KiOmedine ® Carboxymethyl-Chitosan (CM-Chitosan), a novel fluid implant, was safe and effective for treating symptomatic OA. Objective: The objective of this study describe the efficacy single injection CM-Chitosan in ...

To find a precise, efficient, and safe method to control rice sheath blight disease (caused by Rhizoctonia solani ), this study used the natural product magnolol as fungicide. Based on characteristics of cell wall-degrading enzymes (CWDEs) released R. during early stages infection, Mag@CMCS@CPSG (magnolol@carboxymethyl chitosan@carboxymethyl cellulose, pectin, sodium alginate, glycerol) film wa...

Chitosan is a natural polymer which has limited solubility. Chitosan gets solubilized at acidic pH but is insoluble at basic pH. In the present study, carboxymethyl chitosan (CMC) was prepared which shows high swelling in basic pH and thus can delay the drug release and can act as matrix for extended release formulation. CMC was characterized by FTIR and NMR. pH-sensitive hydrogels of theophyll...

In order to fabricate antimicrobial carboxymethyl chitosan-nanosilver (CMC-Ag) hybrids with controlled silver release, this study demonstrated comparable formation via three synthetic protocols: 1) carboxymethyl chitosan (CMC) and glucose (adding glucose after AgNO3), 2) CMC and glucose (adding glucose before AgNO3), and 3) CMC only. Under principles of green chemistry, the synthesis was conduc...

Carboxymethyl sago pulp (CMSP) with a degree of substitution 0.8 was synthesised from waste and cross-linked chitosan to form hydrogel by electron beam (EB) irradiation. Diclofenac sodium loaded into 40% CMSP/3% solution mixture irradiated at 25 kGy. The exhibited pH temperature-sensitive swelling behaviour. Fourier-transform infrared spectroscopy, field emission scanning microscope, X-ray diff...