Allyl sulphides are reactive substrates in ruthenium-catalysed olefin metathesis reactions, provided each substrate is matched with a suitable catalyst. A profile of catalyst activity is described, along with the first demonstration of allyl sulphides as traceless promoters in relayed ring-closing metathesis reactions.

Objective: In the present research work, aim was to prepare pH trigged in-situ ocular gel of Cetirizine Hydrochloride (CTZ) improve its local bioavailability at eye surface. Methods: CTZ prepared by pH-trigged method. In-situ a pH-sensitive gelling agent (Carbomer) with one-viscosity builder polymer (HPMC E4M). All formulation evaluated for appearance, pH, viscosity different capacity, % drug c...

The effects of surfactant polyacrylate acid (PAA) on shape evolution of 0.7Pb(Mg1/3Nb2/3)O3-0.3PbTiO3 (0.7PMN-0.3PT) nanorods were studied. The results revealed that the polyacrylic acid content had great influence on the morphology of 0.7PMN-0.3PT. With increasing PAA concentration from 0.45 to 0.82 g/ml, the ratio of perovskite phase (PMN-PT nanorod) increased, while the ratio of pyrochlore p...

BACKGROUND Acyclovir has pharmacokinetic limitations, including poor oral bioavailability of 15%-30%, high variability, and short elimination half-life of 2.3 hours. These limitations necessitate frequent administration of acyclovir, up to five times daily, leading to poor patient compliance, which in turn leads to a reduction in therapeutic efficacy and development of resistance. METHODS A g...

The current study involves development of oral bioadhesive hydrophilic matrices of hydralazine hydrochloride, and optimization of their in vitro drug release profile and ex vivo bioadhesion against porcine gastric mucosa. A 32 central composite design was employed to systematically optimize the drug delivery formulations containing two polymers, viz., carbomer and hydroxypropyl methyl cellulose...