Aldrin (5 mg/kg/day, p.o.) under nontolerant condition, administered either for a single day or for 12 consecutive days, enhanced locomotor activity (LA) of rats. The increase in LA was greater in rats treated with aldrin for 12 consecutive days than that observed with a single dose. The aim of the present study is to evaluate the involvement of possible interactions of central GABAergic, choli...

INTRODUCTION Parkinson's disease (PD) is a common neurodegenerative disease. In the 1960s, it was shown that the degeneration of dopamine producing neurons in the substantia nigra (SN) caused the motor features of PD. Dopamine replacement with levodopa, a dopamine precursor, resulted in remarkable benefit. Yet, the intermittent administration of levodopa is a major cause of motor complications,...

Progressively blunted response to L-DOPA in Parkinson's disease (PD) is a critical factor that complicates long-term pharmacotherapy in view of the central importance of this drug in management of the PD-related motor disturbance. This phenomenon is likely due to progressive loss of one of the key enzymes involved in the biosynthetic pathway for dopamine in the basal ganglia: aromatic L-amino a...

The effect of dietary tyrosine and phenylalanine on survival of adult female C57BL/6 x DBA/2 F, mice bearing i.p. slowgrowing, moderately pigmented and fast-growing, highly pigmented B16 melanoma tumors was studied alone and in com bination with carbidopa-levodopa methyl ester chemotherapy. These studies tested three different diets: a natural product diet containing 1.09% phenylalanine and 0.6...

Acetylcholine and dopamine are neurotransmitters that play multiple important roles in perception and cognition. Pharmacological cholinergic enhancement reduces excitatory receptive field size of neurons in marmoset primary visual cortex and sharpens the spatial tuning of visual perception and visual cortical fMRI responses in humans. Moreover, previous studies show that manipulation of choline...

Background Levodopa-carbidopa intestinal gel (LCIG) is administered directly to the small intestine of patients with advanced Parkinson's disease (APD) help maintain stable plasma levodopa levels. Objective The objective this study was investigate effect LCIG in reducing polypharmacy for treatment APD. Methods COmedication Study assessing Mono- and cOmbination therapy levodopa-carbidopa inteSti...

Parkinson’s disease (PD) is a progressive central nervous system (CNS) disorder, the cardinal symptoms of which are bradykinesia, resting tremor, muscular rigidity, and impaired postural balance. The lack of dopamine (DA) in the CNS basal ganglia is associated with these symptoms. L-dopa, an immediate precursor of DA, is used to treat PD. Unlike DA, L-dopa penetrates into the CNS where it is co...