An efficient synthesis of carbamate analogues of the NRTI compound stavudine, has been achieved in five steps starting from commercially available thymidine. The synthesis involves conversion of thymidine into stavudine followed by condensation with carbaimidazole derivative obtained from various aromatic and heterocyclic amines in dimethylformamide solvent. The analogues thus obtained were fur...

A general method for the preparation of bis-ureas from bis(o-nitrophenyl) carbonate has been developed. Directional urea synthesis is achieved by sequential amine addition to bis(o-nitrophenyl) carbonate in two steps: in the first step bis(o-nitrophenyl) carbonate is reacted with benzylamine to form benzyl-o-nitrophenyl carbamate; in the second step the carbamate is reacted with a variety of di...

We have investigated the effect of molecular carbon dioxide, i.e., formation of carbamino compounds on (a) the partial pressure of oxygen at 50% saturation (&,,) of hemoglobin and (b) the Bohr effect when expressed as A log &o/ApH in the following human hemoglobins: Arr (a&), Frr (azrz), AI, (w&~‘~), and FIacetY1 (czz-r2acety1). Some experiments of this kind were also carried out with hemoglobi...

The determination of serum copper is of value in a number of metabolic studies, particularly in the investigation of the anemia of chronic infection. Presented here, together with illustrative data, is a method for determining copper in serum, based on the direct extraction of copper carbamate from serum with isoamyl alcohol. Burch et aa. in their method for serum iron have demonstrated that su...

We have investigated the effect of molecular carbon dioxide, i.e., formation of carbamino compounds on (a) the partial pressure of oxygen at 50% saturation (&,,) of hemoglobin and (b) the Bohr effect when expressed as A log &o/ApH in the following human hemoglobins: Arr (a&), Frr (azrz), AI, (w&~‘~), and FIacetY1 (czz-r2acety1). Some experiments of this kind were also carried out with hemoglobi...

Direct excitation and {1H}13C-CPMAS NMR allowed detecting carbamate–ammonium ion pairs, carbamic acid bicarbonate species in amine-modified silica sorbents.

AMP and its blends are an attractive solvent for CO2 capture, but the underlying reaction mechanisms still remain uncertain. We attempt to elucidate the factors enhancing bicarbonate production in aqueous AMP as compared to MEA which, like most other primary amines, preferentially forms carbamate. According to our predicted reaction energies, AMP and MEA exhibit similar thermodynamic favorabili...

Various treatment protocols were designed to investigate sister chromatid exchanges (SCEs) induced over successive posttreatment cell cycles in bone marrow and alveolar macrophage cells following treatment of C57BL/6J X DBA/2J F1 mice by i.p. injection of ethyl carbamate (3.3 mmol/kg). The same initial extent of alkylation in bone marrow and alveolar macrophages was suggested by identical SCE f...

Methomyl (ME) is a carbamate insecticide that causes change in biochemical parameters and affects the oxidative state body through production of free radicals. Herbal medicines deri...

a gas chromatography mass spectrometry with spike calibration curve method was used to quantify three carbamate pesticides residue in cooked white rice and to estimate the reduction percentage of the cooking process duration. the selected pesticides are three carbamate pesticides including carbaryl and pirimicarb that their mrl is issued by “the institute of standards of iran” and propoxur whic...