Aim and Objective: This research was done to observe the anti-inflammatory effect of moxibustion and explore the role of Transient Receptor Potential Vanilloid sub type 1 (TRPV1) on Mice with adjuvant arthritis. Method: Adjuvant arthritis (AA) was established by using the amount of 20 μL of Freund’s Adjuvant Complete (FCA) intradermal injected into right hindfoot plantar. 50 KM mice were random...

During dermal injury and the associated trauma a number of compounds are released that can mediate the inflammatory response. Determining the cellular mechanisms that initiate the inflammatory responses to acute keratinocyte damage is important for understanding the regulation of epidermal inflammation. The recently cloned vanilloid receptor-1 (VR1) is a polymodal receptor, responding to therma...

Recently, the cannabinoid (CB) receptor agonist anandamide (AEA) has been shown to excite perivascular terminals of primary sensory neurons via activation of the vanilloid receptor-1 (VR-1). To determine whether AEA stimulates central terminals of these neurons, via VR-1 activation, we studied the release of calcitonin gene-related peptide (CGRP)- and substance P (SP)-like immunoreactivities (L...