Candida albicans in the immunocompetent host is a benign member of the human microbiota. Though, when host physiology is disrupted, this commensal-host interaction can degenerate and lead to an opportunistic infection. Relatively little is known regarding the dynamics of C. albicans colonization and pathogenesis. We developed a C. albicans cell surface protein microarray to profile the immunogl...

Population-based surveillance for candidemia in Australia from 2001 to 2004 identified 1,095 cases. Annual overall and hospital-specific incidences were 1.81/100,000 and 0.21/1,000 separations (completed admissions), respectively. Predisposing factors included malignancy (32.1%), indwelling vascular catheters (72.6%), use of antimicrobial agents (77%), and surgery (37.1%). Of 919 episodes, 81.5...

We present a case of Candida dubliniensis meningitis that developed 2 months after apparently successful treatment of an episode of C. dubliniensis candidemia in a heart-lung transplant recipient in Australia. This case highlights the importance of follow-up in patients with candidemia or disseminated infection, especially in immunosuppressed patients.

STUDY OBJECTIVES To develop and prospectively validate models of independent predictors of candidemia and candidemia-related death in cardiothoracic ICU (CICU) patients. DESIGN (1) An initial, prospective, one-center, case-control, independent predictor-model determining study; and (2) a prospective, two-center, model-validation study. SETTING The initial study was performed at the 14-bed C...

BACKGROUND Recent reports have demonstrated a decline in bacterial bloodstream infections (BSIs) following adherence to central line insertion practices; however, declines have been less evident for BSIs due to Candida species. METHODS We conducted active, population-based laboratory surveillance for candidemia in metropolitan Atlanta, GA and Baltimore, MD over a 5-year period. We calculated ...

Background and Purpose: Candidemia is one of the most important fungal infections caused by Candida species. Infections and mortality caused by Candida species have been on a growing trend during the past two decades. The resistance of yeasts to antifungal drugs and their epidemiological issues have highlighted the importance of accurately distinguishing the yeasts at the species level. The tec...

We present a fatal case of persistent neonatal candidemia by Candida parapsilosis following omphalocele, without other anomalies. Despite an encouraging initial prognosis, after surgical correction and closure of the abdominal wall the case became difficult to treat, as in addition to the exposure of the patient to multiple risk factors for candidemia, antifungal therapy apparently was not adeq...

Candidaemia is a bloodstream infection (BSIs) caused by Candida spp. common in hospitalized patients. Candidemia has high mortality and morbidity. This study aimed to give an idea about incidence, patient characteristics, species patterns of candida susceptibility, risk factors candidaemia patients at Dr. Soetomo Hospital from January December 2020. descriptive research using observational desi...

The COVID-19 pandemic has been linked to secondary infections. Candidemia, a fungal healthcare-associated infection, described in patients hospitalized with severe COVID-19. Risk factors for developing include older age, malignancies, obesity, immunocompromised conditions, and chronic diseases, many of which are also risk candidemia. This study aimed compare clinical characteristics candidemia ...

Candida is a common cause of oral mucous membrane and skin infections in newborn infants. Disseminated candidiasis and Candidemia have become a frequent problem in neonatal intensive care unit [1]. Candida species are frequently encountered as part of the human commensal flora. Colonization by Candida spp. is the most impor tant risk factor for development of Candidemia and IFI in pre mature in...