The idea of successive mutations to trigger the appearance of a cancerous cell goes back to at least Muller (1951). The first mathematical model proposed for this phenomenon goes back to Armitage and Doll (1954). There has been a great deal of discussion on the number of successive mutations necessary to get a cancerous cell. It seems that this number depends on the organ, see Knudson (1971) an...

Glycosphingolipids were analyzed from colonic tumors and histologically normal adjacent tissues, obtained at surgery from eight patients. Detailed analysis was carried out on six neutral glycolipids from normal colonic mucosa and cancerous tissues. Their structures were established by permethylation, use of glycosidases, and immunological methods. In the cancerous tissues, lactosylceramide was ...

In the past decade, a high incidence of somatic mitochondrial DNA (mtDNA) mutations has been observed, mostly based on a fraction of the molecule, in various cancerous tissues; nevertheless, some of them were queried due to problems in data quality. Obviously, without a comprehensive understanding of mtDNA mutational profile in the cancerous tissue of a specific patient, it is unlikely to discl...

? some 4 months ago. A small sore resulted, which, instead of healing, has gone on steadily increasing in size. There is a good deal of shooting pain, difficulty in speaking and swallowing, and much distress generally. On admission into the Medical College Hospital a few days ago a large epithelioma with cracked fungating base and indurated everted edges was seen occupying the right side of ton...

The expression of immunoglobulins by cancer cells have been known for two decades. However, the mechanisms of action behind these cancerous immunoglobulins (cIgG) are not well understood and may be different from immunoglobulins secreted by normal B lymphocytes. Therefore, the structural and functional roles of cIgG have been actively investigated to resolve this mystery. A monoclonal antibody,...