In this paper we show how Boolean genetic networks could be used to address complex problems in cancer biology. First, we describe a general strategy to generate Boolean genetic networks that incorporate all relevant biochemical and physiological parameters and cover all of their regulatory interactions in a deterministic manner. Second, we introduce "realistic Boolean genetic networks" that pr...

premature ventricular contraction (pvc) is one of the common cardiac arrhythmias. the occurrence of pvc is dangerous in people who have recently undergone heart. a pvc beat can easily be diagnosed by a doctor based on the shape of the electrocardiogram signal. but in automatic detection, extracting several important features from each beat is required. in this paper, a method for automatic dete...

community detection is a task of fundamental importance in social network analysis. community structures enable us to discover the hidden interactions among the network entities and summarize the network information that can be applied in many applied domains such as bioinformatics, finance, e-commerce and forensic science. there exist a variety of methods for community detection based on diffe...

BACKGROUND Prostate cancer, a serious genetic disease, has known as the first widespread cancer in men, but the molecular changes required for the cancer progression has not fully understood. Availability of high-throughput gene expression data has led to the development of various computational methods, for identification of the critical genes, have involved in the cancer. METHODS In this pa...

Fuzzy neural network methods have been successfully used to diagnose many diseases. This paper uses logic-based fuzzy neural networks to diagnose breast cancer. Logic-based fuzzy neural networks can select reduced size of input subspace by selecting useful inputs. For the optimization of the input subspace and the structure of the logic-based fuzzy neural networks, genetic algorithms and gradie...

BACKGROUND Breast cancer survivors, particularly those treated with chemotherapy, are at significantly increased risk for long-term cognitive and neurobiologic impairments. These deficits tend to involve skills that are subserved by distributed brain networks. Additionally, neuroimaging studies have shown a diffuse pattern of brain structure changes in chemotherapy-treated breast cancer survivo...