In this study we suggested a new strategy for drug delivery of 6-thioguanine (6-TG) as a cancer drug by loading of this thiolic drug at a surface of Au nanoparticles. For this goal, we synthesized Au nanoparticle (Au/NPs) by reduction of tetrachloroauric (III) acid solutions by sodium borohydride and characterized Au/NPs by X-ray powder diffraction (XRD), dynamic light scattering (DLS), Ultravi...

Malignant tumors of head and neck carcinomas are the sixth most common type of cancer. Current systemic therapies for cancer show side effects in normal tissues and short-term efficacy due to drug resistance. Consequently, there is much interest in identifying new drugs for cancer treatment. Crocin (an active ingredient of saffron) has been shown to have cytotoxic effects on cancer cell lines. ...

Abstract Background Nanoparticulate drug delivery systems have attracted significant attention in the field of cancer nanotechnology. This study determines the effect of folate-based Fe2O3 nanoparticles. This study aimed to decorate nanoparticles with folate (FA), a molecular ligand for ‘active’ targeting of cancerous cells and the application of modified-nanoparticles in cancer treatment. ...

Introduction: For thousands of years, plants have been used as the main source of drug worldwide. Recently, it has been found out that the plant Artemisia annua and especially its derivatives such as artemether have anticancer properties. Methods: In this study, the anticancer effect of artemether on MCF-7 breast cancer cell line was examined. MTT assay was used to assess the viability of c...

Abstract Cancer is one of the main causes death worldwide, being pancreatic cancer second deadliest in Western countries. Surgery, chemotherapy and radiotherapy form basis cancer’s current treatment. However, these techniques have several disadvantages, such as surgery complications, systemic side effects recurrence. Drug delivery systems can reduce effects, increasing effectivity treatment by ...

Drug hypersensitivity reactions (DHR) have potential for significant morbidity and mortality, without clear treatment severe reactions. Standard of care is to immediately stop culprit drug(s) never rechallenge. However, the drug and/or whether patient would develop a form DHR unknown. Even if reaction severe, may no alternative their underlying disease. Analysis bulk transcriptional profiling s...

background and objectives: there is a growing trend towards investigating natural products as sources of compounds with biological effects and many researches have been carried out in order to find effective medications against many diseases. cancer is no exception and studies focusing on evaluating the effects of different materials on dna, give valuable information in cancer researches and ca...

Objective(s): Irinotecan is a potent anti-cancer drug from camptothecin group which inhibits topoisomerase I. Recently, biodegradable and biocompatible polymers such as poly lactide-co-glycolides (PLGA) have been considered for the preparation of nanoparticles (NPs). Materials and Methods: In this study, irinotecan loaded PLGA NPs were fabricated by an emulsification/solvent diffusion method to...