A 5-year-old male with a history of frequent upper respiratory infections presented following a motor vehicle crash as an unrestrained, ejected passenger. CT of the chest and abdomen showed a small liver laceration, multifocal peripheral lung opacities ( fig. 1 , black arrows) and extensive lung laceration ( fig. 1 , white arrow). The patient required supplemental oxygen, but no surgical interv...

A simple, fast method to evaluate acute changes of tight junctional permeability in isolated hepatocyte couplets is proposed. The method consists of the recording of the number of canalicular vacuoles able to retain the previously accumulated fluorescent bile acid analogue cholyl-lysyl-fluorescein (CLF), as visualized by inverted fluorescent microscopy, following acute exposure to the compounds...

Rectal lesions without anal sphincter trauma in childbirth are only sporadically described in literature. We describe the case of a 29-year-old primigravida who delivered a child in frank breech presentation. During the second stage of labour a foot presented transanally through a rectal laceration with intact anal sphincters. The laceration was repaired immediately after delivery in theatre. F...

PURPOSE To report a new entity discovered in the lacrimal drainage system, a congenital canalicular cyst (as opposed to a diverticulum or canaliculops). METHODS Clinical, radiographic, histopathologic and immunohistochemical findings were reviewed. RESULTS A 49-year-old man developed a left upper eyelid cyst seen by CT scanning to be attached to a small boney spicule. No connection to the l...

The multidrug resistance-associated protein (MRP) family plays a major role in the hepatic excretion of organic anions. The expression, localization, and function of Mrp2 (Abcc2), a canalicular multispecific organic anion transport protein, were studied in sandwich-cultured rat hepatocytes. The amount of Mrp2 protein remained constant in sandwich-cultured rat hepatocytes over 4 days in culture,...

Metabolism and sinusoidal/canalicular efflux of mycophenolic acid (MPA) was investigated using sandwich-cultured hepatocytes (SCHs). After applying MPA to SCHs from humans, wild-type rats, and multidrug resistance-associated protein (Mrp) 2-deficient rats, the MPA metabolites 7-O-glucuronide (MPAG) and acyl glucuronide (AcMPAG) were detected in the intracellular compartment of the SCHs. Sinusoi...

OBJECTIVE To examine the patterns and predictors of third-degree and fourth-degree laceration in women undergoing vaginal delivery. METHODS We identified a population-based cohort of women in the United States who underwent a vaginal delivery between 1998 and 2010 using the Nationwide Inpatient Sample. Multivariable log-linear regression models were developed to account for patient, obstetric...

Our previous work supports a role for aquaporin-8 (AQP8) water channels in rat hepatocyte bile formation mainly by facilitating the osmotically driven canalicular secretion of water. In this study, we tested whether a condition with compromised canalicular bile secretion, i.e., the estrogen-induced intrahepatic cholestasis, displays defective hepatocyte AQP8 functional expression. After 17alpha...

cardiac laceration from blunt thoracic trauma is not a common presentation. the rate of mortality due to this injury is very high since it is not diagnosed and treated immediately. in this study, we present the case of a 65-year-old man with blunt cardiac trauma, causing right atrial rupture and pericardial tamponade. successful management of this patient was firstly done with initial pericardi...

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