Excessive calcium entry into cells leads to cell death, and voltage-gated calcium channels (VGCCs) are responsible for the calcium entry in the central nervous system. VGCC blockers inhibit excessive calcium entry and protect the central nervous system against various types of injury. The purpose of the present study was to identify the type of calcium channels that is responsible for acoustic ...

An iodide ion-selective PVC membrane sensor based on copper (Π)-bis-Nphenilsalicyldenaminatocomplex as a novel sensing material is successfully developed. Theelectrode showed a good selectivity for iodide ion with respect to common inorganic anions. Thesensor exhibited a good linear response with slope of _58.6 ± 0.4 mV per decade over theconcentration range of 5.0 × 10-6 to 1.0 × 10-1 mol L-1,...

After the intravenous administration of Il'1labeled L-diiodotyrosine (DIT), an increasing fraction of the labeled iodine of the serum becomes inorganic iodide as the DIT undergoes deiodination. Most of the labeled iodine which appears in the urine is inorganic iodide (1). If one makes an estimate of the renal clearance of inorganic iodide, based on the concentrations of labeled inorganic iodide...

The nucleus of the solitary tract (NTS) is the central site of termination of baroreceptor afferents. We hypothesize that changes occur in voltage-gated calcium channels (VGCCs) within NTS neurons as a consequence of hypertension. Whole-cell patch-clamp recordings were obtained from adult normotensive (109+/-2 mm Hg; n=6 from 6 sham-operated and 31 nonsurgically treated) and hypertensive (158+/...

Iodide is a micronutrient essential for thyroid hormone production. The uptake and metabolism of iodide by thyrocytes is crucial to proper thyroid function. Iodide ions are drawn into the thyroid follicular cell via the sodium-iodide symporter (NIS) in the cell membrane and become integrated into tyrosyl residues to ultimately form thyroid hormones. We sought to learn how an abnormal concentrat...

GABA and glycine provide excitatory action during early development: they depolarize neurons and increase intracellular calcium concentration. As neurons mature, GABA and glycine become inhibitory. This switch from excitation to inhibition is thought to result from a shift of intracellular chloride concentration ([Cl-]i) from high to low, but in retina, measurements of [Cl-]i or chloride equili...

PURPOSE sigma-1 Receptor ligands prevent neuronal death associated with glutamate excitotoxicity both in vitro and in vivo. However, the molecular mechanism of the neuroprotective effect remains to be elucidated. The present study was undertaken to determine whether sigma-1 receptor agonists provide neuroprotection by decreasing glutamate-induced calcium mobilization and preventing apoptotic ge...

OBJECTIVES Although many nanomaterials are being used in academia, industry and daily life, there is little understanding about the effects of nanoparticles on the reproductive health of vertebral animals, including human beings. An experimental study was therefore performed here to explore the effect of calcium phosphate nanoparticles on both steroid hormone production and apoptosis in human o...

In 1948, Wolff and Chaikoff reported that organic binding of iodide in the thyroid was decreased when plasma iodide levels were elevated (acute Wolff-Chaikoff effect), and that adaptation or escape from the acute effect occurred in approximately 2 days, in the presence of continued high plasma iodide concentrations. We later demonstrated that the escape is attributable to a decrease in iodide t...