Elevation of extracellular Ca(2+) concentration induces intracellular Ca(2+) signaling in parathyroid cells. The response is due to stimulation of the phospholipase C/Ca(2+) pathways, but the direct mechanism responsible for the rise of intracellular Ca(2+) concentration has remained elusive. Here, we describe the electrophysiological property associated with intracellular Ca(2+) signaling in f...

Ca(2+) imaging and (perforated) patch recording were used to analyze the mechanism of GABA- and glycine-induced depolarizations in lumbar motoneurons of spinal cord slices from fetal rats. In fura-2 ester-loaded cells, the agonist-induced depolarizations increased [Ca(2+)](i) by up to 100 nm. The GABA- and glycine-evoked [Ca(2+)](i) transients were suppressed by bicuculline and strychnine, resp...

the late eocene-early oligocene sarnowsar granitic rocks and many dacitic to rhyolitic dykesintruded in metamorphosed and metasomatized shale, sandstone, calcite and dolomite marbles andvolcaniclastic and pyroclastic rocks. as a result several million tons of iron ores formed within carbonaterocks in the sangan area. the sarnowsar granitic rocks are mainly granite to granodiorite, metaluminous,...

Flavonoids belong to a large group of plant polyphenols that are consumed daily in large amounts. Our previous findings have shown that baicalein, a major flavonoid derived from the medicinal herb Scutellariae radix, induces Cl(-) secretion across rat colonic mucosa. The current study examines the effect of baicalein on Cl(-) secretion in human colonic epithelial (T84) cells and its interaction...

The thrombin receptor, protease-activated receptor-1 (PAR-1), has wide tissue distribution and is involved in many physiological functions. Because thrombin is in the intestinal lumen and mucosa during inflammation, we sought to determine PAR-1 expression and function in human intestinal epithelial cells. RT-PCR showed PAR-1 mRNA expression in SCBN cells, a nontransformed duodenal epithelial ce...

The potential of mean force for the dissociation of a Ca-Cl ion pair in water is calculated from ab initio molecular dynamics simulations. The constraint-force method is employed to enhance sampling over the entire range of the reaction coordinate (Ca-Cl distance) from 2.2 to 6.5 Å. Particular attention is paid to equilibration of the system as it is found that the potential of mean force is hi...

this paper presents results of hydro-chemical processes controlling groundwater chemical composition, using an integrated application of hierarchical cluster analysis and factor analysis of a major ion data set of groundwater from mighan playa aquifer. cluster analysis classified samples into four clusters(a, b, c and d) according to their dominant chemical composition: cluster a (dominant comp...

Physicochemical and ionic characteristics of groundwater aquifers have been tremendous importance in water applications. Groundwater selected coastal communities (Badagry, Epe, Ikorodu, Ilaje/ese-odo) south-western Nigeria was assessed for domestic irrigation suitability. One hundred ninety-two (192) samples were obtained analyzed chemical composition major ratio over a period four seasons usin...