نتایج جستجو برای: c677t

تعداد نتایج: 1675  

Journal: :Genetika 2022

Introduction: Recurrent pregnancy loss (RPL) is defined as two or more consecutive which occurs before the 20th weeks of pregnancies for last menstrual period. Hereditary cause thrombophilic gene mutations and polymorphism may play an essential role in RPLs. Material Method: 291 women with a history abortions study group 61 without miscarriages control were included study. In this we analysed e...

2011
Erika RF Siqueira Cláudia PMS Oliveira Maria TC Muniz Filipe Silva Leila MMB Pereira Flair J Carrilho

BACKGROUND/AIM Hyperhomocysteinemia due to Methylenetetrahydrofolate Reductase (MTHFR) gene, in particular the C677T (Ala222Val) polymorphism were recently associated to steatosis and fibrosis. We analyzed the frequency of MTHFR gene in a cross-sectional study of patients affected by Chronic Hepatitis C (CHC) from Northeast of Brazil. METHOD One hundred seven-four untreated patients with CHC ...

2012
Banu BAYRAM Çetin KILIÇÇI Harun ÖNLÜ Fezan ŞAHİN

In this study, it was aimed to determine the allele frequencies and genotype distributions of MTHFR gene C677T and A1298C polymorphisms in a Turkish study population with polycystic ovary syndrome. Genomic DNA was isolated from blood samples of 30 patients with polycystic ovary syndrome and 28 healthy controls. PCR-RFLP technique was used to analyze MTHFR gene C677T and A1298C polymorphisms. Pr...

2014
Elham Yousefian Mohammad Taghi Kardi Azra Allahveisi

BACKGROUND Recurrent pregnancy loss (RPL) is a serious problem for pregnancy. There is evidence that vascular complications play a principal role in RPL. Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism. Polymorphisms (C677T, A1298C) of MTHFR gene are associated with decreased MTHFR activity. OBJECTIVES The aim of this study was to determine the association bet...

2017
Suh-Mian Wu Zhao-Feng Chen Lufei Young S. Pamela K. Shiao

Background: Alzheimer's disease (AD) is a significant public health issue. AD has been linked with methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, but the findings have been inconsistent. The purpose of this meta-predictive analysis is to examine the associations between MTHFR polymorphisms and epigenetic factors, including air pollution, with AD risk using big data analytics ap...

Journal: :Genetics and molecular research : GMR 2014
J Chen L Yuan Y Q Duan J Q Jiang R Zhang Z J Huang X R Xiao

Folic acid and methylenetetrahydrofolate reductase (MTHFR) may both affect the development of human cancer. We conducted a population-based case-control study in a Chinese population to investigate the potential role of folate intake and MTHFR gene polymorphisms in gastric cancer, and their interaction with infection by Helicobacter pylori and tumor location. A total of 767 patients with newly ...

Journal: :Genetic testing and molecular biomarkers 2012
Ali Sazci Mavi Deniz Ozel Ergul Emel Halil Atilla Idrisoglu

Studies have revealed that elevated homocysteine levels can cause damage to motor neurons through multiple neurotoxic mechanisms, thus leading to the pathogenesis of amyotrophic lateral sclerosis (ALS). One way by which homocysteine levels are increased in the body is the consequence of methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms. Therefore, to address this question, we studi...

2017
Lilin He Yongxiang Shen

OBJECTIVE Previous studies have found that many gene variations can be detected in both breast cancer and ovarian cancer, which is beneficial for the elaboration of the molecular origin of breast and ovarian cancer. Furthermore, many studies have explored the association of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with the risk of breast cancer and/or ovarian cancer; howev...

Journal: :Molecular Vision 2008
Shazia Michael Raheel Qamar Farah Akhtar Wajid Ali Khan Asifa Ahmed

PURPOSE To determine whether or not there is an association of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with disease in cohorts of primary open-angle glaucoma (POAG) and primary closed-angle glaucoma (PCAG) from Pakistan. METHODS This was a prospective study consisting of 150 patients (90 POAG and 60 PCAG) and 70 control subjects. Genomic DNA was extracted from leuko...

2012
Ali Sazci Mavi Deniz Ozel Ergul Emel Halil Atilla Idrisoglu

Studies have revealed that elevated homocysteine levels can cause damage to motor neurons through multiple neurotoxic mechanisms, thus leading to the pathogenesis of amyotrophic lateral sclerosis (ALS). One way by which homocysteine levels are increased in the body is the consequence of methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms. Therefore, to address this question, we studi...

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